Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Chemistry
One-Step Synthesis Of Kanamycin Functionalized Gold Nanoparticles With Potent Antibacterial Activity Against Resistant Bacterial Strains, Hitesh Kumar Waghwani
One-Step Synthesis Of Kanamycin Functionalized Gold Nanoparticles With Potent Antibacterial Activity Against Resistant Bacterial Strains, Hitesh Kumar Waghwani
Masters Theses & Specialist Projects
On the verge of entering the post-antibiotic era, numerous efforts are in place to regain the losing potential of antibiotics which are proving ineffective against common bacterial infections. Engineered nanomaterials, especially gold nanoparticles (GNPs) capped with antibacterial agents are proving to be an effective and novel strategy against multi-drug resistant (MDR) bacteria. In this study, we report a one-step synthesis of kanamycin-capped GNPs (20 ± 5 nm) utilizing the combined reducing and capping ability of the aminoglycoside antibiotic, kanamycin. Antibacterial assays showed dosedependent broad spectrum activity of Kan-GNPs against Gram-positive (Staphylococcus epidermidis and Enterococcus durans), Gram-negative (Escherichia coli and Enterobacter …
Antimicrobial Nanoparticles: A Green And Novel Approach For Enhancing Bactericidal Efficacy Of Commercial Antibiotics, Monic Shah
Masters Theses & Specialist Projects
On the verge of entering the post-antibiotic era, numerous efforts are in place to regain the waning charm of antibiotics which are proving ineffective against most “Superbugs”. Engineered nanomaterials, especially gold nanoparticles (GNPs) capped with antibacterial agents, are proving to be an effective and novel strategy against multidrug resistant (MDR) bacteria. In this study, we report a one-step synthesis of antibioticcapped GNPs (25 ± 5 nm) utilizing the combined reducing and capping ability of a cephalosporin antibiotic, ceftazidime. No signs of aggregation or leaching of ceftazidime from GNP surface was observed upon its storage. Antibacterial testing showed dosedependent broad spectrum …
A New Class Of Gold Nanoantibotics - Direct Coating Of Ampicillin On Gold Nanoparticles, Dillon S. Pender
A New Class Of Gold Nanoantibotics - Direct Coating Of Ampicillin On Gold Nanoparticles, Dillon S. Pender
Mahurin Honors College Capstone Experience/Thesis Projects
Need for novel, innovative strategies for developing antibiotics is becoming a necessity due to an increasing number of rapidly evolving micro-organismal threats. Antibiotic encapsulated gold nanoparticles (GNPs) are one such strategy showing promise. We report the development of ampicillin encapsulated gold nanoparticles (Amp-GNPs) that possess highly effective, dose dependant antibacterial activity. In this method, ampicillin molecules have been coated on individual GNPs which can then serve as drug carrier devices. Our method for synthesizing Amp-GNPs is an entirely ecofriendly, single step reaction taking place in an aqueous buffer. Following characterization of Amp-GNPs, we find them to be ~15 nm in …