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Full-Text Articles in Chemistry
Computational Enzymology On Sulfur-Containing Enzymes: From Method To Application, Paul Meister
Computational Enzymology On Sulfur-Containing Enzymes: From Method To Application, Paul Meister
Electronic Theses and Dissertations
Sulfur-containing biomolecules display incredible functional diversity. Indeed, in addition to thiols and thioethers, S-nitrosothiols, 3,4-coordinate, sulfoxides, persulfides and now even polysulfides are commonly observed intermediates. Unfortunately, however, their biological synthesis and roles remain poorly understood. In addition, sulfur-containing species can access a broad range of oxidation states and thus can act as either an electrophile or nucleophile giving rise to an even more diverse set of sulfur-derived functional groups. However, these unique properties can lead to difficulties in characterizing such compounds experimentally and reinforces the need for computational studies to reliably predict their structural and energetic properties. In this dissertation, …
Examining Biomolecular Interactions And Their Significance In Toxoplasma Gondii Survival And Infection, Grace Wen
Electronic Theses and Dissertations
Elucidating biomolecular interactions that underlie the cellular processes vital to the survival and infectivity of the parasitic protozoan Toxoplasma gondii is crucial for development of effective prophylactics and therapeutics against this resilient pathogen. In the first two parts of this three-part study, the significance of protein-protein, protein-nucleic acid, and protein-lipid interactions in T. gondii pathogenicity is explored. The first part of the study presents an overview of current knowledge on the topic of liquid-liquid phase separation, which is the condensation of macromolecules driven by multivalent interactions between protein and protein or protein and nucleic acids, and its multifaceted role in …
Computational Enzymology On Sulfur-Containing Enzymes: From Method To Application, Paul Meister
Computational Enzymology On Sulfur-Containing Enzymes: From Method To Application, Paul Meister
Electronic Theses and Dissertations
Sulfur-containing biomolecules display incredible functional diversity. Indeed, in addition to thiols and thioethers, S-nitrosothiols, 3,4-coordinate, sulfoxides, persulfides and now even polysulfides are commonly observed intermediates. Unfortunately, however, their biological synthesis and roles remain poorly understood. In addition, sulfur-containing species can access a broad range of oxidation states and thus can act as either an electrophile or nucleophile giving rise to an even more diverse set of sulfur-derived functional groups. However, these unique properties can lead to difficulties in characterizing such compounds experimentally and reinforces the need for computational studies to reliably predict their structural and energetic properties. In this dissertation, …