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Full-Text Articles in Chemistry
Extrasynaptic Localization Is Essential For Α5gabaa Receptor Modulation Of Dopamine System Function, Alexandra M. Mccoy, Thomas D. Prevot, Md Yeunus Mian, Dishary Sharmin, Adeeba N. Ahmad, James M. Cook, Etienne L. Sibille, Daniel J. Lodge
Extrasynaptic Localization Is Essential For Α5gabaa Receptor Modulation Of Dopamine System Function, Alexandra M. Mccoy, Thomas D. Prevot, Md Yeunus Mian, Dishary Sharmin, Adeeba N. Ahmad, James M. Cook, Etienne L. Sibille, Daniel J. Lodge
Chemistry Faculty Publications and Presentations
Dopamine system dysfunction, observed in animal models with psychosis-like symptomatology, can be restored by targeting gamma-aminobutyric acid type A receptors (GABAARs) containing the α5, but not α1, subunit in the ventral hippocampus (vHipp). The reason for this discrepancy in efficacy remains elusive; however, one key difference is that gamma-aminobutyric acid type A receptors containing the α1 subunit (α1GABAARs) are primarily located in the synapse, whereas gamma-aminobutyric acid type A receptors containing the α5 subunit (α5GABAARs) are mostly extrasynaptic. To test whether receptor location is responsible for this difference in efficacy, we injected an siRNA into the vHipp to knock down …