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Secondary Structure Adopted By The Gly-Gly-X Repetitive Regions Of Dragline Spider Silk, Geoffrey M Gray, Arjan Van Der Vaart, Chengchen Guo, Justin Jones, David Onofrei, Brian R Cherry, Randolph V Lewis, Jeffery L Yarger, Gregory P Holland
Secondary Structure Adopted By The Gly-Gly-X Repetitive Regions Of Dragline Spider Silk, Geoffrey M Gray, Arjan Van Der Vaart, Chengchen Guo, Justin Jones, David Onofrei, Brian R Cherry, Randolph V Lewis, Jeffery L Yarger, Gregory P Holland
Chemistry Faculty Publications
Solid-state NMR and molecular dynamics (MD) simulations are presented to help elucidate the molecular secondary structure of poly(Gly-Gly-X), which is one of the most common structural repetitive motifs found in orb-weaving dragline spider silk proteins. The combination of NMR and computational experiments provides insight into the molecular secondary structure of poly(Gly-Gly-X) segments and provides further support that these regions are disordered and primarily non-β-sheet. Furthermore, the combination of NMR and MD simulations illustrate the possibility for several secondary structural elements in the poly(Gly-Gly-X) regions of dragline silks, including β-turns, 3