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Fabrication And Application Of Functional Polymer-Protein Coreshell Nanoparticles, Lin Lu
Fabrication And Application Of Functional Polymer-Protein Coreshell Nanoparticles, Lin Lu
Theses and Dissertations
The study of polymer-protein nanoparticles is of increasing interest due to their various potential applications in biosensing, imaging, bioseparations, gene and drug delivery, etc. Synthetic polymers can be tailored with different functional groups and properties, therefore, they can serve as platforms to impart proteins with additional features and assist proteins to better perform biological functions. In this dissertation work, we were mainly focusing on the preparation of polymer-protein core-shell nanoparticles by synthesizing new functional polymers and assembling them with proteins for different applications. In chapter 1, a pyridine grafted diblock copolymer P(CL-g-Py)-b-PCL was prepared through ROP and CuAAC reactions. …
Structural And Functional Studies Of Nicotinamide Adenine Dinucleotide And Streptolysin S Biosynthesis Proteins From Streptococcus Pyogenes, William T. Booth
Structural And Functional Studies Of Nicotinamide Adenine Dinucleotide And Streptolysin S Biosynthesis Proteins From Streptococcus Pyogenes, William T. Booth
Theses and Dissertations
Invasive infections caused by Streptococcus pyogenes, also known as Group A Strep (GAS), results in approximately 600,000 deaths annually. With evidence of antibiotic-resistant strains of this bacterium on the rise, there is a need for the identification of new drug targets to control these infections. In our approach we target the quinolinate-salvage pathway (QSP) and the streptolysin S (SLS) biosynthesis pathway. The QSP provides a secondary pathway for NAD+ biosynthesis within this organism; the SLS pathway leads to the formation of a quorum sensing molecule (SLS). We hypothesize that inhibition of the pathways will lead to GAS cell death or …
Ligand Engineering For Advanced Functional Composite Materials, Michael H. Bell
Ligand Engineering For Advanced Functional Composite Materials, Michael H. Bell
Theses and Dissertations
The surface modification of solid inorganic substrates for thermodynamic compatibility with organic polymer media has become an important area of study for the development of advanced functional composite materials. Polymer ligands covalently bound to the substrate surface have been an effective means to achieve said compatibility. Current investigations focus on multifunctional ligand engineering where multiple chemically distinct species, each with specific functionality, can be implemented on the filler surface simultaneously. A combination of matrix compatible polymer brushes and conjugated charge trapping moieties attached to filler surfaces are investigated for enhancements in dielectric properties. Presented herein are the synthesis and characterization …