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Full-Text Articles in Chemistry
Ahr Expression On Rorc-Expressing Immune Cells Is Essential For I3c-Mediated Protection Against Colitis, Michal C. Williams
Ahr Expression On Rorc-Expressing Immune Cells Is Essential For I3c-Mediated Protection Against Colitis, Michal C. Williams
Senior Theses
Colitis is an inflammatory bowel disorder (IBD) whose etiology is attributed to modification in the luminal microbiota and dysregulation in the immune response. Indole is a signaling molecule which is naturally produced by gut luminal microbiota. Indole-3- carbinol (I3C) is a compound commonly found in vegetables and a ligand for the aryl hydrocarbon receptor (AhR). Previous studies have detected decreased expression and activation on the AhR receptor in colitis patients, thought to possibly alter gut microbiota metabolism, subsequently promoting colitis. 1 AhR, expressed in a variety of immune and epithelial cells, contributes to gut homeostasis by affecting vital mediators such …
Plant Virus Based Materials For Cell Alignment And Differentiation, Elizabeth Balizan
Plant Virus Based Materials For Cell Alignment And Differentiation, Elizabeth Balizan
Theses and Dissertations
This research focused on developing and using plant virus based scaffolds to understand substrate control over cell alignment and differentiation. The first part of this work centered on development of virus based patterns that were then used to align and elongate aortic smooth muscle cells (SMCs). Virus patterns were generated in capillary tubes via a simple drying method. Three experimental parameters were used to control pattern formation: (1) protein concentration, (2) salt concentration, and (3) hydrophobicity of the pre-deposition surface. By controlling these parameters several aspects of the final virus patterns were controlled. First, virus orientation was controlled. Patterns were …
Biomaterial-Induced Osteogenesis Of Mesenchymal Stem Cells By Surface Roughness And Functionalization, Pongkwan Sitasuwan
Biomaterial-Induced Osteogenesis Of Mesenchymal Stem Cells By Surface Roughness And Functionalization, Pongkwan Sitasuwan
Theses and Dissertations
For tissue engineering and regenerative medicine, it is important to understand factors directing the stem cell fate, including self-renewal, proliferation, differentiation, and apoptosis. Bone marrow derived mesenchymal stem cells (BMSCs) have the potential to differentiate into osteoblasts, chondrocytes, adipocytes, and smooth muscle cells. Specifically, in the field of bone tissue engineering, BMSCs are commonly used for in vitro osteogenesis studies. However the mechanisms and signaling pathways that these cells recognize material surface and utilize to differentiate are still unclear. This dissertation focuses on investigating the effect of surface nanotopography and functionalization on the promotion of osteogenic differentiation of BMSCs. Surface …