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Mitochondrial Proteins In Mediating Colon Cancer And Potential Theraputics, Kunlun Yin
Mitochondrial Proteins In Mediating Colon Cancer And Potential Theraputics, Kunlun Yin
Chemistry and Chemical Biology ETDs
Cancer is one of the biggest threatens to human health. Colon cancer is one of the leading causes of new incidence and mortality in the whole world. It is important to understand the mechanism of tumorigenesis and development. Based on the mechanisms, we may develop new therapeutics to improve survival rate.
In Chapter 2, we discussed the PINK1 function in suppression colon cancer. We found that PINK1 can activate its substrate P53, which activates its downstream targets during mitophay. At the same time, PINK1 is also involved in metabolism, we showed that PINK1 can reduce Acetyl-CoA by inhibiting PDHE1ɑ. Cells …