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Rhodium-Catalyzed Asymmetric Hydrogenation Using Self-Assembled Chiral Bidentate Ligands, James M. Takacs, Kittichai Chaiseeda, Shin A. Moteki, D. Sahadeva Reddy, Di Wu, Kusumlata Chandra

James Takacs Publications

The chirality-directed self-assembly of bifunctional subunits around a structural metal-typically, zinc(II)-is used to form a heteroleptic complex in which a second set of ligating groups are suitably disposed to bind a second metal, forming a heterobimetallic catalyst system. We find that subtle changes in the structural backbone (i.e., ligand scaffold) of such chiral bidentate self-assembled ligands (SALs) can be used to manipulate the ligand topography and chiral environment around catalytic metal; thus, the scaffold can be optimized to maximize asymmetric induction. Using this combinatorial strategy for ligand synthesis, a preliminary study was carried out in which a library of 110 …