Chemistry Commons^™

Interactions Between Amyloid-Beta And Microglial Cells, Lisa Gouwens

Dissertations

Alzheimer’s disease (AD), the most common cause of dementia, is a neurodegenerative condition characterized by loss of memory and intellectual abilities. Intracellular plaques of aggregated amyloid-beta (Ab) protein are a well-known pathology associated with AD. Although symptoms usually appear late in life, the accumulation of Ab begins decades earlier and causes activation of microglia, the brain’s immune cells. The ensuing inflammation contributes significantly to neurodegeneration. Determination of the particular form of Ab that causes the most damage in the brain is one of the major questions in the AD field. My research focused on the interactions of microglia with monomers, …

Cadmium Chloride Dimensionality Changes From Ortho-Substituted Anilines, Stephanie Cernicek

Dissertations

Inorganic-organic hybrid metal halide materials have been of great interest recently due to the useful properties offered by such a combination. The inorganic portions usually consisting of MX₆^2- subunits, (M = Pb, Sn, Cd, Cu; X = Cl, Br, I) most often form 2-D perovskite layers where the metals are bridged by corner sharing halides. The organic portion, usually consisting of primary amines or anilines provides a template for the inorganic framework and in some cases, dictates the dimensionality (2-D, 1-D, 0-D) of the network. These materials have various applications in host-guest chemistry catalysis, and gas storage, or …

Syntheses, Structures And Magnetic Properties Of Cyano-Bridged Transition Metal Compounds, Uma Prasad Mallik

Dissertations

To investigate the hypotheses, that systematically changing the electronic and relative sizes of tricyanido building blocks will tune magnetic properties of their cluster derivatives, we prepared two new tricyanido pyrazolylborate complexes, [NEt₄][(Tp*^Me)­Fe(CN)₃]­·H₂O and [NEt₄]­[(Tp^*Bn)­Fe^III(CN)₃]­·H₂O·MeOH, and investigated their self-assembly. The new building blocks were prepared, structurally characterized, and their coordination chemistry explored to prepare small molecule-based magnetic materials.

Three bent trinuclear ferromagnetic cluster derivatives of {[(Tp^*Me)­Fe^III(CN)₃]_2­[Ni^II(L)₂]}·n(solvent) [L = …