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Full-Text Articles in Chemistry
Dna Functionalized Nanoparticles In Nanobiosensor And Sensor Array Development For Molecular Diagnostics And In Vitro Identification Of Biomolecules, Mustafa Salih Hizir
Dna Functionalized Nanoparticles In Nanobiosensor And Sensor Array Development For Molecular Diagnostics And In Vitro Identification Of Biomolecules, Mustafa Salih Hizir
Legacy Theses & Dissertations (2009 - 2024)
Nucleic acid technology along with vast variety of nanomaterials has demonstrated a great potential in many applications from biosensing studies to molecular diagnostics, from biomedical and bioanalytical research to environmental analysis. Especially short single stranded (ss) DNA molecules, called oligonucleotides, are extraordinary biopolymers featuring diverse functionality on the nanoparticles thanks to their high degree of programmability, target-specific binding or cleavage, molecular recognition ability, structure-switching capability, and unique interactions at the bio-nano interfaces. Among those, there have been many biosensing applications utilizing ss DNAs and numerous nanomaterials through various detection techniques such as fluorometric, colorimetric or electrochemical methods. Although many groundbreaking …
Synthesis And Base Pairing Studies Of 5-Cyanomethyl Uridine (Cnm⁵U) And 5-Cyano Uridine (Cn⁵U) In Rna Duplex, Hsu-Chun Tsai
Synthesis And Base Pairing Studies Of 5-Cyanomethyl Uridine (Cnm⁵U) And 5-Cyano Uridine (Cn⁵U) In Rna Duplex, Hsu-Chun Tsai
Legacy Theses & Dissertations (2009 - 2024)
RNA plays an essential role in many biological processes by acting as both genetic information carriers, catalyst and regulator. Natural RNAs usually contain nucleoside analogs from the four common ribonucleosides. There are over 150 chemical modification have been discovered in natural RNA molecules. 5-cyanomethyl uridine is a native modification that has been discovered in total tRNAs from Haloarcula marismortui. This modification in the anticodon wobble position affects the codon recognition, and leads the mutant tRNA to bind not only to AUA but also to AUU and AUG. We synthesized 5-cyanomethyl uridine (cnm5U) and its derivative 5-cyanouridine (cn5U), which has the …
Technology Development For Detection Of Circulating Disease Biomarkers From Liquid Biopsies Using Multifunctional Nanomaterials, Mustafa Balcioglu
Technology Development For Detection Of Circulating Disease Biomarkers From Liquid Biopsies Using Multifunctional Nanomaterials, Mustafa Balcioglu
Legacy Theses & Dissertations (2009 - 2024)
Despite the advance health care, devastating health conditions such as cancer and infectious diseases that affect populations worldwide are too often not diagnosed until morbid symptoms become apparent in the late phase. Obtaining an early and accurate diagnosis that reveal a hidden lethal threat before the disease becomes complicated may dramatically reduce the severity of its impact on the patient’s life and increase the probability of survival. For example, in the case of ovarian cancer, which is the fifth most common malignancy and the fifth leading cause of cancer mortality in women in the US, the 5-year relative survival is …