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Articles 1 - 8 of 8
Full-Text Articles in Chemistry
The Role Of Particle Surface Functionality And Microstructure Development In Isothermal And Non-Isothermal Crystallization Behavior Of Polyamide 6/Cellulose Nanocrystals Nanocomposites, Shahram Rahimi, Joshua U. Otaigbe
The Role Of Particle Surface Functionality And Microstructure Development In Isothermal And Non-Isothermal Crystallization Behavior Of Polyamide 6/Cellulose Nanocrystals Nanocomposites, Shahram Rahimi, Joshua U. Otaigbe
Faculty Publications
Polyamide 6 (PA6)/cellulose nanocrystal (CNC) and aminopropyl triethoxy silane (APS) - modified CNC nanocomposites were prepared by in situ anionic ring opening polymerization and subsequent melt extrusion. The morphological observation of these hybrid systems revealed that the non-modified nanocrystals developed a network-like fibrillar structure while the APS-modified CNCs were finely dispersed mostly as individual whiskers. The isothermal and non-isothermal crystallization kinetics was extensively studied with emphasis on the effects of CNC surface functionality and the subsequent microstructure development on crystallization behavior of these novel nanocomposite systems. The non-modified CNC particles with corresponding fibrillar microstructure were found significantly hinder the crystallization …
Block Ionomer Complexes Consisting Of Sirna And ARaft-Synthesized Hydrophilic-Block-Cationic Copolymers Ii: The Influence Of Cationic Block Charge Density On Gene Suppression, Keith Hampton Parsons, Andrew Christopher Holley, Gabrielle A. Munn, Alex S. Flynt, Charles L. Mccormick
Block Ionomer Complexes Consisting Of Sirna And ARaft-Synthesized Hydrophilic-Block-Cationic Copolymers Ii: The Influence Of Cationic Block Charge Density On Gene Suppression, Keith Hampton Parsons, Andrew Christopher Holley, Gabrielle A. Munn, Alex S. Flynt, Charles L. Mccormick
Faculty Publications
Block ionomer complex (BIC)–siRNA interactions and effectiveness in cell transfection are reported. Aqueous RAFT polymerization was used to prepare a series of hydrophilic-block-cationic copolymers in which the cationic block statistically incorporates increasing amounts of neutral, hydrophilic monomer such that the number of cationic groups remains unchanged but the cationic charge density is diluted along the polymer backbone. Reduced charge density decreases the electrostatic binding strength between copolymers and siRNA with the goal of improving siRNA release after targeted cellular delivery. However, lower binding strength resulted in decreased transfection and RNA interference pathway activation, leading to reduced gene knockdown. Enzymatic siRNA …
A New Class Of Allosteric Hiv-1 Integrase Inhibitors Identified By Crstallographic Fragment Screening Of The Catalytic Core Domain, Disha Patel, Janet Antwi, Pratibha C. Koneru, Erik Serrao, Stefano Forli, Jacques J. Kessl, Lei Feng, Nanjie Deng, Ronald M. Levy, James R. Fuchs, Arthur J. Olson, Alan N. Engelman, Joseph D. Bauman, Mamuka Kvaratskhelia, Eddy Arnold
A New Class Of Allosteric Hiv-1 Integrase Inhibitors Identified By Crstallographic Fragment Screening Of The Catalytic Core Domain, Disha Patel, Janet Antwi, Pratibha C. Koneru, Erik Serrao, Stefano Forli, Jacques J. Kessl, Lei Feng, Nanjie Deng, Ronald M. Levy, James R. Fuchs, Arthur J. Olson, Alan N. Engelman, Joseph D. Bauman, Mamuka Kvaratskhelia, Eddy Arnold
Faculty Publications
HIV-1 integrase (IN) is essential for virus replication and represents an important multifunctional therapeutic target. Recently discovered quinoline-based allosteric IN inhibitors (ALLINIs) potently impair HIV-1 replication and are currently in clinical trials. ALLINIs exhibit a multimodal mechanism of action by inducing aberrant IN multimerization during virion morphogenesis and by competing with IN for binding to its cognate cellular cofactor LEDGF/p75 during early steps of HIV-1 infection. However, quinoline-based ALLINIs impose a low genetic barrier for the evolution of resistant phenotypes, which highlights a need for discovery of second-generation inhibitors. Using crystallographic screening of a library of 971 fragments against the …
C60 And Sc3N@C80(Tmb-Ppo) Derivatives As Constituents Of Singlet Oxygen Generating, Thiol-Ene Polymer Nanocomposites, Emily M. Barker, Ashli R. Toles, Kyle A. Guess, J. Paige Buchanan
C60 And Sc3N@C80(Tmb-Ppo) Derivatives As Constituents Of Singlet Oxygen Generating, Thiol-Ene Polymer Nanocomposites, Emily M. Barker, Ashli R. Toles, Kyle A. Guess, J. Paige Buchanan
Faculty Publications
Numerous functionalization methods have been employed to increase the solubility, and therefore, the processability of fullerenes in composite structures, and of these radical addition reactions continue to be an important methodology. C60 and Sc3N@C80 derivatives were prepared via radical addition of the photodecomposition products from the commercial photoinitiator TMB-PPO, yielding C60(TMB-PPO)5 and Sc3N@C80(TMB-PPO)3 as preferred soluble derivatives obtained in high yields. Characterization of the mixture of isomers using standard techniques suggests an overall 1PPO:6TMB ratio of addends, reflecting the increased reactivity of the carbon radical. Although, a higher …
Crystal Structure Of Di-Aqua-Bis-(7-Di-Ehtyl-Amino-3-Formyl-2-Oxo-2h-Chromen-4-Olato-Κ(2) O (3), O (4))Zinc(Ii) Dimethyl Sulfoxide Disolvate, Aaron B. Davis, Frank R. Fronczek, Karl J. Wallace
Crystal Structure Of Di-Aqua-Bis-(7-Di-Ehtyl-Amino-3-Formyl-2-Oxo-2h-Chromen-4-Olato-Κ(2) O (3), O (4))Zinc(Ii) Dimethyl Sulfoxide Disolvate, Aaron B. Davis, Frank R. Fronczek, Karl J. Wallace
Faculty Publications
The structure of the title coordination complex, [Zn(C14H14NO4)2(H2O)2]·2C2H6OS, shows that the ZnII cation adopts an octahedral geometry and lies on an inversion center. Two organic ligands occupy the equatorial positions of the coordination sphere, forming a chelate ring motif via the O atom on the formyl group and another O atom of the carbonyl group (a pseudo--diketone motif). Two water molecules occupy the remaining coordination sites of the ZnII cation in the axial positions. The water molecules are each hydrogen bonded to …
Wrinkled1 Rescues Feedback Inhibition Of Fatty Acid Synthesis In Hydroxylase-Expressing Seeds, Neil D. Adhikari, Philip D. Bates, John Browse
Wrinkled1 Rescues Feedback Inhibition Of Fatty Acid Synthesis In Hydroxylase-Expressing Seeds, Neil D. Adhikari, Philip D. Bates, John Browse
Faculty Publications
Previous attempts at engineering Arabidopsis (Arabidopsis thaliana) to produce seed oils containing hydroxy fatty acids (HFA) have resulted in low yields of HFA compared with the native castor (Ricinus communis) plant and caused undesirable effects, including reduced total oil content. Recent studies have led to an understanding of problems involved in the accumulation of HFA in oils of transgenic plants, which include metabolic bottlenecks and a decrease in the rate of fatty acid synthesis. Focusing on engineering the triacylglycerol assembly mechanisms led to modest increases in the HFA content of seed oil, but much room for …
Polymer Chain Dynamics In Epoxy Based Composites As Investigated By Broadband Dielectric Spectroscopy, Mohammad K. Hassan, Samuel James Tucker, Ahmed Abukmail, Jeffrey S. Wiggins, Kenneth A. Mauritz
Polymer Chain Dynamics In Epoxy Based Composites As Investigated By Broadband Dielectric Spectroscopy, Mohammad K. Hassan, Samuel James Tucker, Ahmed Abukmail, Jeffrey S. Wiggins, Kenneth A. Mauritz
Faculty Publications
Epoxy networks of the diglycidyl ether of bisphenol A (DGEBA) were prepared using 3,3′- and 4,4′-diaminodiphenyl sulfone isomer crosslinkers. Secondary relaxations and the glass transitions of resultant networks were probed using broadband dielectric spectroscopy (BDS). A sub-Tg γ relaxation peak for both networks shifts to higher frequencies (f) with increasing temperature in Arrhenius fashion, both processes having the same activation energy and being assigned to phenyl ring flipping in DGEBA chains. A β relaxation is assigned to local motions of dipoles that were created during crosslinking reactions. 4,4′-based networks exhibited higher Tg relative to 3,3′-based …
Molecular Scale Cure Rate Dependence Of Thermoset Matrix Polymers, Christopher Harold Childers, Mohammad K. Hassan, Kenneth A. Mauritz, Jeffrey S. Wiggins
Molecular Scale Cure Rate Dependence Of Thermoset Matrix Polymers, Christopher Harold Childers, Mohammad K. Hassan, Kenneth A. Mauritz, Jeffrey S. Wiggins
Faculty Publications
This manuscript demonstrates the molecular scale cure rate dependence of di-functional epoxide based thermoset polymers cured with amines. A series of cure heating ramp rates were used to determine the influence of ramp rate on the glass transition temperature (Tg) and sub-Tg transitions and the average free volume hole size in these systems. The networks were comprised of 3,3′-diaminodiphenyl sulfone (33DDS) and diglycidyl ether of bisphenol F (DGEBF) and were cured at ramp rates ranging from 0.5 to 20 °C/min. Differential scanning calorimetry (DSC) and NIR spectroscopy were used to explore the cure ramp rate dependence of the polymer network …