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Matrix Effects, Development Of Clean-Up And Lc-Techniques Contributing Towards A Reference Lcms Method For The Analysis Of Lipophilic Marine Toxins, Mairead Anne Mcelhinney
Matrix Effects, Development Of Clean-Up And Lc-Techniques Contributing Towards A Reference Lcms Method For The Analysis Of Lipophilic Marine Toxins, Mairead Anne Mcelhinney
Masters
The most widely used reference method in Europe for the detection and monitoring of lipophilic marine toxins is the Mouse Bioassay (MBA) as first described by Yasumoto et al., (1978). The MBA offers a good level of protection to human health and is capable of detecting the overall toxicity of previously known toxins. However, there are drawbacks associated with the use of the MBA as it is both expensive and time consuming and can give false positives due to interferences (Suzuki et al, 1976). The problems associated with the original mouse bioassay have led to several modifications (Yasumoto et al, …