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Preparation, Structure Elucidation, And Antioxidant Activity Of New Bis(Thiosemicarbazone) Derivatives, Hasan Yakan
Preparation, Structure Elucidation, And Antioxidant Activity Of New Bis(Thiosemicarbazone) Derivatives, Hasan Yakan
Turkish Journal of Chemistry
Schiff-base-bearing new bis(thiosemicarbazone) derivatives were prepared from terephthalaldehyde and various thiosemicarbazides. FT--IR,$^{\, 1}$H NMR, $^{13}$C NMR, and UV--Vis spectroscopic methods and elemental analysis were used to elucidate the identification of the synthesized molecules. The in vitro antioxidant activity of the synthesized compounds was analysed with the 1,1-diphenyl-2-picryl hydrazyl free-radical-trapping process. The synthesized compounds exhibited lower antioxidant activity than the standard ascorbic acid. IC$_{50}$ values of the synthesized molecules measured from 3.81 $\pm $ 0.01 to 29.05 $\pm $ 0.11 $\mu$M. Among the synthesized compounds, compound 3 had the best antioxidant activity. Moreover, this study explained the structure--activity relationship of the …
Synthesis, Spectroscopic Studies, And Antioxidant Activities Of Novelthio/Carbohydrazones And Bis-Isatin Derivatives From Terephthalaldehyde, Hali̇t Muğlu, Hasan Yakan, Temel Kan Bakir
Synthesis, Spectroscopic Studies, And Antioxidant Activities Of Novelthio/Carbohydrazones And Bis-Isatin Derivatives From Terephthalaldehyde, Hali̇t Muğlu, Hasan Yakan, Temel Kan Bakir
Turkish Journal of Chemistry
New bis(isatins-thio/carbohydrazones) based on Schiff bases were prepared from terephthalaldehyde biscarbohydrazone and 5-substituted isatins in the presence of a drop of sulfuric acid under reflux in ethanol. Terephthalaldehyde bis(thio/carbohydrazone) was synthesized by the reaction of (thio)/carbohydrazide and terephthalaldehyde in the presence of a few drops of acetic acid under reflux in ethanol. The structures of these synthesized compounds were determined using IR, $^{1}$H NMR, and $^{13}$C NMR spectroscopy and elemental analysis. The in vitro antioxidant activity of all the compounds was determined by the 1,1-diphenyl-2-picryl hydrazyl (DPPH.) free radical scavenging method. Compound 2 showed the best antioxidant activity.