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Synthesis, Biological Evaluation Of Antioxidant-Antibacterial Activities And Computational Studies Of Novel Anthracene- And Pyrene-Based Schiff Base Derivatives, Ayşegül Gümüş, Veysi̇ Okumuş, Selçuk Gümüş
Synthesis, Biological Evaluation Of Antioxidant-Antibacterial Activities And Computational Studies Of Novel Anthracene- And Pyrene-Based Schiff Base Derivatives, Ayşegül Gümüş, Veysi̇ Okumuş, Selçuk Gümüş
Turkish Journal of Chemistry
Schiff base derivatives with anthracene- and pyrene-based units, A1-A6 and P1-P6 were synthesized (89%-99% yields). Schiff base derivatives were designed to possess an heterocyclic moiety on one side to enhance the coordination ability towards metals. To investigate the biological assay of the newly synthesized compounds, their DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, metal chelating, reducing power, antibacterial and DNA binding activities were tested. A6 (63.1%) showed the maximum free radical scavenging activity among all. However, compound P3 at concentration of 200 \textmu g/mL possessed the highest metal chelating (45.8%) activity and power of reduction. In addition, P3 and A6 showed antibacterial activity …
Synthesis, Antioxidant And Antimicrobial Properties Of Novel Pyridyl-Carbonyl Thiazoles As Dendrodoine Analogs, Zafer Şahi̇n, Sevde Nur Bi̇lteki̇n, Leyla Yurttaş, Şeref Demi̇rayak
Synthesis, Antioxidant And Antimicrobial Properties Of Novel Pyridyl-Carbonyl Thiazoles As Dendrodoine Analogs, Zafer Şahi̇n, Sevde Nur Bi̇lteki̇n, Leyla Yurttaş, Şeref Demi̇rayak
Turkish Journal of Chemistry
Marine compound dendrodoine was first obtained from tunicate species (Dendrodo grossularia). It has a five-membered ring, namely, it is a heterocycle thiadiazole, which is found rarely in natural sources. Following its biological activities, novel analogs have been investigated recently. Synthesis of the analogs for this study is realized with uncommon thiazole closure, including methylene-carbonyl condensation. Structures are elucidated by NMR (1H, 13C) and HRMS spectrums. As an alkaloid derivative, antioxidant properties were evaluated with DPPH and FRAP assays and antimicrobial effect with microdilution method. Among the series, 3bc-3cf showed higher antioxidant activity than those having 3 or 4-pyridyl substituents. There …