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Synthesis, Anticandidal Activity, And Cytotoxicity Of Some Thiazole Derivatives With Dithiocarbamate Side Chains, Leyla Yurttaş, Yusuf Özkay, Fati̇h Demi̇rci̇, Gamze Göger, Şafak Ulusoylar Yildirim, Usama Abu Mohsen, Ömer Öztürk, Zafer Asim Kaplancikli
Synthesis, Anticandidal Activity, And Cytotoxicity Of Some Thiazole Derivatives With Dithiocarbamate Side Chains, Leyla Yurttaş, Yusuf Özkay, Fati̇h Demi̇rci̇, Gamze Göger, Şafak Ulusoylar Yildirim, Usama Abu Mohsen, Ömer Öztürk, Zafer Asim Kaplancikli
Turkish Journal of Chemistry
Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a--j) were confirmed by spectral data (IR, ^1H NMR, ^{13}C NMR, and MS) and elemental analysis. The anticandidal activity of the compounds was determined (6a--j) using the microbroth dilution method and their cytotoxicity was evaluated according to the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against normal cells. Contrary to expectations, weak antifungal activity was observed with IC_{50} values ranging between 30 and 403 \mu g/mL.