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Novel Method For The Spectrophotometric Determination Of Isoniazid And Ritodrine Hydrochloride, Padmarajaiah Nagaraja, Kallanchira Sunitha, Ramanathapura Vasantha, Hemmige Yathirajan
Novel Method For The Spectrophotometric Determination Of Isoniazid And Ritodrine Hydrochloride, Padmarajaiah Nagaraja, Kallanchira Sunitha, Ramanathapura Vasantha, Hemmige Yathirajan
Turkish Journal of Chemistry
A simple, rapid and sensitive spectrophotometric method for the determination of isoniazid (INH) and ritodrine hydrochloride (RTH) in pure form as well as dosage forms is described. The method is based on the diazotisation of 4,4'-sulphonyldianiline (dapsone, DAP) followed by a coupling reaction with either INH or RTH in sodium hydroxide medium. Beer's law is obeyed in the concentration range of 0.5-20 \mu g ml^{-1} for INH at 440 nm and 0.5-18 \mu g ml^{-1} for RTH at 460 nm. The method is successfully employed for the determination of INH/RTH in pharmaceutical preparations and the results agree favourably with the …
Spectrophotometric Determination Of Mexiletine Hydrochloride In Capsules Using Bromothymol Blue, Zeynep Aydoğmuş, S. Müge Çeti̇n, Sedat Tosunoğlu
Spectrophotometric Determination Of Mexiletine Hydrochloride In Capsules Using Bromothymol Blue, Zeynep Aydoğmuş, S. Müge Çeti̇n, Sedat Tosunoğlu
Turkish Journal of Chemistry
A new spectrophotometric method based on the formation of an ion-pair using bromothymol blue as ion-pair complexing reagent was developed for the determination of mexiletine hydrochloride in capsules. The ion-pair formed was highly coloured and easily extracted with dichloromethane. The calibration curve was linear over the concentration range 1.08--10.8 \mu g.ml^{-1} at \lambda_{max} = 408 nm (r = 0.9999). The results obtained from the developed method were compared statistically with those obtained by the British Pharmacopeia method.
A Spectrophotometric Method For The Determination Of Prazosin Hydrochloride In Tablets, Mahmure Üstün Özgür, Sidika Sungur
A Spectrophotometric Method For The Determination Of Prazosin Hydrochloride In Tablets, Mahmure Üstün Özgür, Sidika Sungur
Turkish Journal of Chemistry
A rapid and sensitive analytical method was developed for the spectrophotometric assay of prazosin hydrochloride. The method is based on the formation of a coloured derivative between the drug and 1,2-naphthoquinone-4- sulphonic acid sodium salt (NQS). The reaction proceeds quantitatively at pH 4.5 and 70°C for 40 min. After the extraction of the derivative with chloroform: n-butanol (3:1), the absorbance was measured at 400 nm. The method was applied to commercially available tablets and the results were statistically compared with those obtained by ultraviolet spectrophotometric and differential pulse polarographic methods using t- and F-tests.