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Full-Text Articles in Chemistry
Enlarging The Stokes Shift By Weakening The Π-Conjugation Of Cyanines For High Signal-To-Noise Ratiometric Imaging, Yongkang Yue, Tingting Zhao, Zhou Xu, Weijie Chi, Xiaojun Chai, Jiahong Ai, Jiawei Zhang, Fangjun Huo, Robert M. Strongin, Caixia Yin
Enlarging The Stokes Shift By Weakening The Π-Conjugation Of Cyanines For High Signal-To-Noise Ratiometric Imaging, Yongkang Yue, Tingting Zhao, Zhou Xu, Weijie Chi, Xiaojun Chai, Jiahong Ai, Jiawei Zhang, Fangjun Huo, Robert M. Strongin, Caixia Yin
Chemistry Faculty Publications and Presentations
The signal-to-noise ratio (SNR) is one of the key features of a fluorescent probe and one that often defines its potential utility for in vivo labeling and analyte detection applications. Here, it is reported that introducing a pyridine group into traditional cyanine-7 dyes in an asymmetric manner provides a series of tunable NIR fluorescent dyes (Cy-Mu-7) characterized by enhanced Stokes shifts (≈230 nm) compared to the parent cyanine 7 dye (nm). The observed Stokes shift increase is ascribed to symmetry breaking of the Cy-Mu-7 core and a reduction in the extent of conjugation. The fluorescence signals of the Cy-Mu-7 dyes …