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Full-Text Articles in Chemistry
Functionalization, Growth And Applications Of Single Wall Carbon Nanotubes, Yubing Wang
Functionalization, Growth And Applications Of Single Wall Carbon Nanotubes, Yubing Wang
Dissertations
Because of their remarkable structural, mechanical and electrical properties, carbon nanotubes, and especially single wall carbon nanotubes (SWNTs), represent one of the most widely investigated materials today in the emerging field of nanotechnology. The development of oriented growth of SWNTs critical for applications, novel approaches for the creation of functional SWNTs, and applications of both as-prepared and chemically functionalized SWNTs for electrochemically-induced hydrogen storage, in-situ formation of new polymer and ceramic nanocomposites with SWNTs, and the fabrication and study for the first time, to the best of our knowledge, of a SWNT-based biofuel cell and self-powered biosensor, are the thrusts …
Modeling Of Flexible Drug-Like Molecules : Qsar Of Gbr 12909 Analog Dat/Sert Selectivity, Kathleen Mary Gilbert
Modeling Of Flexible Drug-Like Molecules : Qsar Of Gbr 12909 Analog Dat/Sert Selectivity, Kathleen Mary Gilbert
Dissertations
The dopamine reuptake inhibitor GBR 12909 and related dialkyl piperazine and piperidine analogs have been studied as agonist substitution therapies acting on the dopamine transporter (DAT) to treat cocaine addiction. Undesirable binding to the serotonin transporter (SERT) can vary greatly depending on the specific substituents on the molecule. This study uses Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices (CoMSIA) techniques to determine a stable and predictive model for DAT/SERT selectivity for a set of flexible GBR 12909 analogs.
Families of analogs were constructed from six pairs of naphthyl-substituted piperazine and piperidine templates identified by hierarchical clustering as …