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Full-Text Articles in Chemistry
Synthesis, Characterization, And Self-Assembly Of Porphyrins Conjugated To Superparamagnetic Colloidal Particles For Enhanced Photodynamic Therapy, Javoris Hollingsworth
Synthesis, Characterization, And Self-Assembly Of Porphyrins Conjugated To Superparamagnetic Colloidal Particles For Enhanced Photodynamic Therapy, Javoris Hollingsworth
LSU Doctoral Dissertations
Porphyrins and their derivatives are often used as photosensitizers in photodynamic therapy (PDT), which is a noninvasive antitumor treatment. The photochemical process for PDT involves exciting a photosensitizing agent with visible light, which induces cytotoxicity in the presence of oxygen as a result of forming reactive oxygen species (ROS). The ROS are the responsible components for invoking cell death and destruction of tumors. Although this mechanism is an effective cancer therapeutic, it still has many shortcomings. One major challenge of PDT concerns improving the tumor selectivity and specificity of photosensitizers because porphyrins have nonspecific affinity to tumor cells. The discussed …
Synthesis, Cellular Studies, And Computational Analysis Of Porphyrin And Bodipy Conjugates With Affinity For Epidermal Growth Factor Receptor, Alecia Michelle Mccall
Synthesis, Cellular Studies, And Computational Analysis Of Porphyrin And Bodipy Conjugates With Affinity For Epidermal Growth Factor Receptor, Alecia Michelle Mccall
LSU Doctoral Dissertations
Chapter 1 is a description of the basic fundamental concepts of porphyrins and BODIPYs, (including synthetic methodologies), a general mechanism of the processes of EGFR, and computational concepts that are elaborated upon in future chapters. Chapter 2 is a discussion solely on the porphyrins that were synthesized to be used as fluorophores for EGFR-targeted conjugates, both peptidic and non-peptidic. The porphyrins were primarily synthesized via the Lindsey method as well as by O-alkylation of tetrahydroxy porphyrins. Synthesis of PEG linkages are discussed as well through three methodologies. Chapter 3 is a presentation of the synthesis, characterization, cellular studies, and computational …