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Full-Text Articles in Chemistry
Double Stranded Dna-Binding Studies Of Potential Rhodium(Ll) Antitumor Complexes, Amity Elizabeth Burr
Double Stranded Dna-Binding Studies Of Potential Rhodium(Ll) Antitumor Complexes, Amity Elizabeth Burr
Honors Theses
In 1952, Dwyer and coworkers began testing a series of metal complexes for potential inhibition of cancer cell proliferation in animals.[l] The complexes tested were unsuitable for such studies due to their high toxicity. Therefore, no further work was done on the project. However, in 1965, Rosenberg and coworkers revisited the possibility of potential metal-based drugs. Serendipitously, they discovered that cis-diamminedichloroplatinum(lI) (cisplatin) inhibits cell division in E. coli.[2] Further studies of this and other platinum compounds revealed inhibition of tumor cell lines sarcoma 180 and leukemia LI2l0 in mice.[l] Cisplatin was approved by the Food and Drug Administration in 1970 …
Effect Of 6-Thioguanine And Methyl-6-Thioguanine On Stability Of Dna Duplexes, Mabaera Rodwell
Effect Of 6-Thioguanine And Methyl-6-Thioguanine On Stability Of Dna Duplexes, Mabaera Rodwell
Honors Theses
6-Thioguanine (65G) has been used for the past thirty years as an anti-cancer agent in maintenance chemotherapy for childhood acute lymphoblastic leukemia as well as acute myeloid leukemia. Despite its long-standing clinical use, little is understood of the molecular basis of the cytotoxicity associated with ?sG. Research has shown that ?sG is incorporated into DNA during replication after which it may exert its cytotoxicity by inducing rapid mutation or by affecting DNA-protein interactions. 65G has also been shown to impair HIV replication by inhibiting HlV-l reverse transcriptase and to inhibit human telomerase activity. To further understand the structural changes associated …