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In Vitro And In Vivo Effects Of A Cyclooxygenase-2 Inhibitor Nimesulide Analog Jcc76 In Aromatase Inhibitors-Insensitive Breast Cancer Cells, Bo Zhong, Xiaohan Cai, Xing Yi, Aimin Zhou, Shiuan Chen, Bin Su
In Vitro And In Vivo Effects Of A Cyclooxygenase-2 Inhibitor Nimesulide Analog Jcc76 In Aromatase Inhibitors-Insensitive Breast Cancer Cells, Bo Zhong, Xiaohan Cai, Xing Yi, Aimin Zhou, Shiuan Chen, Bin Su
Chemistry Faculty Publications
Third generation aromatase inhibitors (AIs) are more effective than tamoxifen in the treatment of estrogen receptor (ER) positive breast cancer. However, long-term use of AIs commonly results in resistance. We examined whether compound JCC76{Cyclohexanecarboxylic acid [3-(2,5-dimethyl-benzyloxy)-4-(methanesulfonyl-methyl-amino)-phenyl]-amide}, an analog of Cyclooxygenase-2 (COX-2) inhibitor nimesulide, can inhibit the growth of AI-insensitive breast cancer cells and the mechanisms by which the compound affects cell proliferation. LTEDaro (long term estrogen deprived MCF-7aro cell) cells, which are a model for AI resistance, were used in this study. JCC76 effectively inhibited LTEDaro cell proliferation with an IC50 of 2.75 ± 0.31 μM. Further investigations reveal that …