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Full-Text Articles in Chemistry
Synthesis Of A Spacer-Armed Disulfated Tetrasaccharide Of Sb1a, A Carbohydrate Hapten Associated With Human Hepatocellular Carcinoma, Qin Li, Hui Li, Qing Li, Qing Hua Lou, Bin Su, Meng Shen Cai, Zhong Jun Li
Synthesis Of A Spacer-Armed Disulfated Tetrasaccharide Of Sb1a, A Carbohydrate Hapten Associated With Human Hepatocellular Carcinoma, Qin Li, Hui Li, Qing Li, Qing Hua Lou, Bin Su, Meng Shen Cai, Zhong Jun Li
Chemistry Faculty Publications
A disulfated tetrasaccharide fragment with a spacer arm of human hepatocellular carcinoma carbohydrate antigen SB1a, namely, 2-aminoethyl 3-O-sulfo-β-d-galactopyranosyl-(1→3)-2-acetamido-2-deoxy-β-d-galactopyranosyl-(1→4)-3-O-sulfo-β-d-galactopyranosyl-(1→4)-β-d-glucopyranoside was synthesized via a [2+1+1] block building mode. In the last coupling step toward the trisaccharide acceptor 8, benzoyl protected galactosyl bromide donor 14 was found to be much more reactive than the acetyl-protected donors. A disulfated tetrasaccharide fragment with a spacer arm of human hepatocellular carcinoma carbohydrate antigen SB1a was synthesized via a [2+1+1] block building mode.
Rapid Determination Of Serum Melatonin By Esi–Ms–Ms With Direct Sample Injection, Shuming Yang, Xiaohui Zheng, Yan Xu, Xiang Zhou
Rapid Determination Of Serum Melatonin By Esi–Ms–Ms With Direct Sample Injection, Shuming Yang, Xiaohui Zheng, Yan Xu, Xiang Zhou
Chemistry Faculty Publications
This paper describes a rapid, simple and sensitive analytical method for the quantitative determination of melatonin in human serum by ESI–MS–MS with direct serum sample injection and on-line extraction. The method uses N-acetyltryptamine as the internal standard. It has high specificity and sensitivity for serum melatonin analysis. The internal calibration curve shows a wide linear range from 0.500 to 200 ng/ml with a correlation coefficient, R2>0.999. The limit of quantitation is 0.500 ng/ml and the limit of detection is 0.100 ng/ml with 10-μl sample injection. The recoveries of serum melatonin at three levels are approximately 70%. The intra-assay precision …
Chemical Imaging Comes Of Age, John F. Turner Ii
Chemical Imaging Comes Of Age, John F. Turner Ii
Chemistry Faculty Publications
Sophisticated analysis techniques allow researchers to extract meaningful results from spectral imaging data.