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Full-Text Articles in Chemistry
How To Fold And Protect Mitochondrial Ribosomal Rna With Fewer Guanines, Maryam Hosseini, Poorna Roy, Marie Sissler, Craig L. Zirbel, Eric Westhof, Neocles B. Leontis
How To Fold And Protect Mitochondrial Ribosomal Rna With Fewer Guanines, Maryam Hosseini, Poorna Roy, Marie Sissler, Craig L. Zirbel, Eric Westhof, Neocles B. Leontis
Chemistry Faculty Publications
Mammalian mitochondrial ribosomes evolved from bacterial ribosomes by reduction of ribosomal RNAs, increase of ribosomal protein content, and loss of guanine nucleotides. Guanine is the base most sensitive to oxidative damage. By systematically comparing high-quality, small ribosomal subunit RNA sequence alignments and solved 3D ribosome structures from mammalian mitochondria and bacteria, we deduce rules for folding a complex RNA with the remaining guanines shielded from solvent. Almost all conserved guanines in both bacterial and mammalian mitochondrial ribosomal RNA form guaninespecific, local or long-range, RNA–RNA or RNA– protein interactions. Many solvent-exposed guanines conserved in bacteria are replaced in mammalian mitochondria by …
Polymers Course For Small Colleges And Universities, Joseph Furgal
Polymers Course For Small Colleges And Universities, Joseph Furgal
Chemistry Faculty Publications
This article describes the course design and teaching methodology for a polymer chemistry and applications lecture class specifically aimed at small college and university instruction. This intermediate course for advanced undergraduates and masters level graduate students focuses on teaching the basics of polymer history, synthesis and characterization with connections to the core chemistry curriculum in a small class size environment and without a textbook. Furthermore, an extensive overview of the applications of polymeric materials gives students a connection to real life applications. The course includes polymer case studies, informational lessons on real world objects made of polymers, and demonstrations. Student …