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Articles 1 - 7 of 7
Full-Text Articles in Chemistry
Localization Of Sodium, Potassium-Adenosine Triphosphatase In The Cerebral Cortex Of Developing Rats, Maki Ujiie
Localization Of Sodium, Potassium-Adenosine Triphosphatase In The Cerebral Cortex Of Developing Rats, Maki Ujiie
Loma Linda University Electronic Theses, Dissertations & Projects
Active transport via Na+, K+-ATPase plays an important role in establishing and maintaining proper ionic gradient across all mammalian cell membranes. A strict regulation of Na+, and K+ ion levels is especially important in excitable cells such as neurons and myocytes. Inhibition of the enzyme is associated with several pathological conditions and has serious detrimental effects on cerebral cortical cells. Yet the enzyme appears to be limited in amount and distribution in newborn rats. In this study, Na+, K+- ATPase expression and distribution in early postnatal rats were studied …
A Method For The Determination Of Purity Of Pnu-10483 Bulk Drug By Capillary Zone Electrophoresis, Gavin Gibson
A Method For The Determination Of Purity Of Pnu-10483 Bulk Drug By Capillary Zone Electrophoresis, Gavin Gibson
Honors Theses
In this investigation, a method was developed for the determination of purity of the drug PNU-10483 using the technique of capillary zone electrophoresis (CZE). CZE was seen as a potential alternative to the formerly used procedure of ion-pair reversed phase highperformance liquid chromatography (HPLC). Nearly five years earlier, a similar study was performed, in which an attempt was made to develop a method that used CZE to determine the purity of bulk drug and the potency of drug tablets. While this development was mostly successful, sporadically unpredictable results reduced the method's overall viability. These outliers were thought to be caused …
Substituted Polythiophenes From Highly Reactive Zinc Reagents, Reuben D. Rieke
Substituted Polythiophenes From Highly Reactive Zinc Reagents, Reuben D. Rieke
Chemistry Department: Faculty Publications
A novel Zerovalent zinc species and an organozinc reagent are disclosed. The zerovalent zinc species is directly pro duced by reaction of a reducing agent on a zinc salt, preferably Zn(CN)2. The organozinc reagent results from the reaction of the zerovalent zinc species and an organic compound having one or more stable anionic leaving groups. These organozinc reagents include a wide spectrum of functional groups in the organic radical, and are useful in a variety of reactions schemes.
Cross-Coupling Of Organic Compounds Using Cuprous Odide, Reuben D. Rieke
Cross-Coupling Of Organic Compounds Using Cuprous Odide, Reuben D. Rieke
Chemistry Department: Faculty Publications
Cross-coupling or addition reactions of organic compounds, including acid halides, allylic halides, and C.B-unsaturated carbonyl containing compounds, with organozinc com pounds may be readily and Safely carried out in the presence of cuprous iodide. The use of this catalyst in the coupling reaction provides for the preparation of commercially useful products in the pharmaceutical, agrochemical and other industries.
Metathesis-Based Synthesis Of Jasmonate And Homojasmonate Lactones, Candidates For Extracellular Quorum Sensing Molecules In Candida Albicans, Su C. Cho, Patrick Dussault, Amber D. Lisec, Ellen C. Jensen, Kenneth W. Nickerson
Metathesis-Based Synthesis Of Jasmonate And Homojasmonate Lactones, Candidates For Extracellular Quorum Sensing Molecules In Candida Albicans, Su C. Cho, Patrick Dussault, Amber D. Lisec, Ellen C. Jensen, Kenneth W. Nickerson
Chemistry Department: Faculty Publications
Ring-closing metathesis of jasmonate esters is shown to provide a rapid entry to jasmonate lactones. The lactones were investigated as possible quorum sensing molecules for the fungi Candida albicans. Assays demonstrated no effect on fungal morphology at concentrations up to 96 mM.
Method For The Synthesis Of Α-Oxranyl Amino Acids, David B. Berkowitz, Michelle L. Pedersen
Method For The Synthesis Of Α-Oxranyl Amino Acids, David B. Berkowitz, Michelle L. Pedersen
Chemistry Department: Faculty Publications
The present invention is related to a novel class of decar-boxylase enzyme inhibitors consisting of α-oxiranyl amino acids and derivatives thereof and a method of synthesizing Such compounds.
Pyrrolic Compounds, Michael J. Therien, Stephen Dimagno
Pyrrolic Compounds, Michael J. Therien, Stephen Dimagno
Chemistry Department: Faculty Publications
Novel methylpyrroles are provided, as well as processes for their preparation.