Chemistry Commons^™

Synthesis Of Photoluminescent Metal-Chalcogen Clusters For Potential Oled Applications, Aaron Mitchell

Undergraduate Student Research Internships Conference

No abstract provided.

Analysis Of Botulinum Toxin A And Interacting Proteins In Skeletal Muscle Cells: An Investigation Into The Mechanisms Of Botulinum Toxin A As A Treatment For Chronic Exertional Compartment Syndrome, Lauren Kee

Pence-Boyce STEM Student Scholarship

Background: Chronic exertional compartment syndrome (CECS) is a condition in which muscle tissue expands against the surrounding fascia during activity and is compressed along with the nerves and blood vessels within the muscle compartment, leading to abnormally high intracompartmental pressure (ICP) and debilitating pain. Treatment typically includes fasciotomy, which results in significant levels of CECS recurrence; however, botulinum toxin A (BoNT-A) injection has recently been seen to decrease both ICP and pain through an unknown mechanism with little to no recurrence.

Methods: In this study, cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), prostaglandin E₂ receptor 4 (EP4), endothelial nitric oxide synthase (eNOS), …

062— Nano-Size Dependence In Aggregation Process Of Beta 2 Microglobulin Coated Gold Colloids, Kaylee A. Hausrath

GREAT Day Posters

The formation of the aggregates of the beta 2 microglobulin (b2m) coated nano-gold colloids were investigated for various nanogold colloid sizes ranging between 10 nm and 100 nm. The aggregation process was considered to be initiated by the selfassembly of b2m by transforming the folded to the unfolded structure under highly acidic condition (pH < 4). The formation of the aggregates were monitored by a peak shift of surface plasmon resonance (SPR) band as a function of number of free b2m available. As for relatively smaller size of gold colloid diameter a gradual aggregation process was observed. The size of the aggregates was considered to increase monotonically as the b2m was added. On the other hand, as for relatively larger diameter of gold colloid, stepwise aggregation process was observed. So that the aggregates of a particular size was formed at a certain threshold of the concentration of available free b2m. The majority of the gold surface of the smaller gold size was easily covered and support the aggregation even at the lower concentration of b2m.

Inhibiting Nitroso Related Methylation Of Guanine Using Dietary Supplements And Flavonoids, Madeline Mccoy, James Davis, Chloe Rippey, Stephen Hobson

Liberty University Research Week

Undergraduate

Basic

Raising Global Awareness And Internationality In The Undergraduate Organic Chemistry Laboratory, Marissa Scilley, Michael R. Korn

Liberty University Research Week

Undergraduate

Applied

Pueraria Montana Peroxidase Activity, Kathryn Briley, Gregory Raner

Liberty University Research Week

Undergraduate

Basic

Synthesis Of Phosphindolizine, Tyler Bell

Campus Research Day

Synthesis of Phosphindolizine which hasn't been done before.

Greening Of Ferrocene Column Chromatography, Marissa Scilley, Anderson Hill, Michael R. Korn

Liberty University Research Week

Undergraduate

Basic

Incorporating The Origin Of Life Theme In Organic Chemistry Laboratories: Analyses Of Amino Acids, Emmalyn Sarver, Michael R. Korn

Liberty University Research Week

Undergraduate

Basic

Deletion Of Ph Response Genes In Cryptococcus Neoformans, Hannah Finson, Michael S. Price

Liberty University Research Week

Undergraduate

Basic

Synthesis Of Some Rhenium-Pyridazyl Complexes For Future Use In Semiconductive Materials, Zachariah Hutcheon, Jonathan Nelson, Philip Temple, Mark Villers, Chad Snyder

Liberty University Research Week

Undergraduate

Basic

Developing An Experiment For General Chemistry Ii, Tyler Fisher

Campus Research Day

I am presenting on my research in figuring out how the electrochem station works for the chemistry department. My goal is to standardize the machine and then design and create an experiment for General Chemistry II Lab.

Synthesis Of Dibenzophosphole Derivatives, Allan Roy Sison

Campus Research Day

This presentation will demonstrate how dibenzophosphole derivatives are synthesized. There will also be studies on the properties of this complex compound. Our experiment is based on previous studies on dibenzophospholes. We will be using the methods from the previous studies and we will synthesize the derivatives of the dibenzophosphole compound using other compounds such as dibromophenol.

"What Lights Up Your "Tech"? - Subtitle: Synthesis Of Polycyclic Aromatic Hydrocarbons (Pah) Using To 2,2-Dibromo-1,1-Binapthalene, Jefferd Daniel

Campus Research Day

The application of this molecule can be used eventually to add several elements like (Bromine, Chlorine, etc.) Previous done research that was conducted was in shortening the process to synthesize PAH. Since then, there has been research conducted to stabilize the compound by closing/linking two of the un-linked benzene rings.

Synthesize phosphyl-paralene, functionalize, and analyze the properties of those molecules and attach its derivatives

Synthesis Of Dibenzophospholes From Biphenyl, Claudia Velasquez

Campus Research Day

The aim is a direct synthesis of various diphenzylphospholes using biphenyl, phosphonic acid, and Tf2O. Successful addition of the phosphonic acid in a one step reaction would result in a more efficient production of the diphenylphospholes.

Products Of An Acid-Catalyzed 1-Methylcyclopentene Reaction, Erin Burke

Campus Research Day

The poster presents research on the alternate products produced from 1-methylcyclopentene across different concentrations of sulfuric acid catalyst.

Carrier-Free Chemo-Ptt/Pdt Ionic Nanomaterials For Combination Cancer Therapy, Samantha Macchi

Arkansas Women in STEM Conference

Herein, we describe a carrier-free combination nanodrug for treatment of cancer. In this work, we combined a photothermal compound and a chemotherapeutic drug using ionic liquid chemistry. We utilized a facile, one-step metathesis approach to replace the counter cation of a near infra-red (NIR) dye (photothermal agent) with a chemotherapeutic cation to synthesize an ionic material-based combination cancer therapy drug to deliver multiple mechanisms simultaneously. The nanodrugs were developed by using a reprecipitation method. The detailed photophysical properties of this new combination therapy molecule was investigated in ethanol solution as well as in nanoparticles forms in aqueous media. The singlet …

Synthesis Of Asymmetrically-Substituted Tetraphenyl-Class Porphyrins, William J. Davis

Summer Scholarship, Creative Arts and Research Projects (SCARP)

No abstract provided.

Luminescent Metal-Organic Frameworks For The Detection Of Alcohols, Lucas Stehle, Kristi A. Kneas, Jeffrey A. Rood

Summer Scholarship, Creative Arts and Research Projects (SCARP)

Metal-organic frameworks (MOFs), porous materials composed of metal ions and organic linkers, have broad applications in separation, small molecule storage, and catalysis. Luminescent metal-organic frameworks (LMOFs) hold great potential in the development of sensors, and, with their relatively straightforward syntheses that produce predictable, homogeneous, extended structures, should result in good sensor-to-sensor reproducibility and uniform response. In addition, subtle differences in overall LMOF structure, metal ion coordination, pore surfaces, and host-guest interactions within pores should have significant impact on observed photoluminescence and provide numerous strategies for analyte detection, which shows promise for the detection of alcohols. Highlighted here is the development …

Synthesis And Characterization Of Oxovanadium Compounds As Potential Insulin Mimetic Molecules, Kaitlyn Mercando, Jeffrey A. Rood

Summer Scholarship, Creative Arts and Research Projects (SCARP)

Oxovanadium(IV) complexes have numerous applications in diverse areas such as catalysts for organic transformations and as anti-fungal agents. Complexes that this research focused on have shown potential in acting as insulin mimetics. The goal of this research was to synthesis and fully characterize a new series of oxovanadium complexes and then investigate the insulin mimetic properties of the complexes with adipose cell culture work. Vanadyl complexes involving a series of salicylaldiminato ligands [C6H5N=CHC6H4OH (L1), 2,6-iPrC6H3N=CHC6H4OH (L2), C6H5N=CH-3,5-tBu2C6H2OH (L3) and 2,6-iPrC6H3N=CH-3,5-tBu2C6H2OH (L4)] were synthesized and structurally characterized. The ligand set was investigated due to the ease of sterically tuning the substituents …

Incorporation Of Luminescent Osmium Complexes Into Metal-Organic Frameworks: Optimization Of Osmium Complex Synthesis And Effect Of Mof Structure On Complex Inclusion And Emission, Brandon A. Molina, Lucas Stehle, Jeffrey A. Rood

Summer Scholarship, Creative Arts and Research Projects (SCARP)

Metal-Organic Frameworks (MOFs) are materials that contain metal centers coordinated by organic molecules that form an extended, porous lattice. These MOFs are of interest in the field of sensing for their unique properties such as high stability, high surface area, high crystallinity, and ability to perform small molecule exchange. Luminescent metal-organic frameworks (LMOFs) are of specific interest since they contain the potential to detect odorless volatile organic compounds (VOCs) via adsorption into the porous framework. Luminescent properties can be imparted to MOFs in several ways. This project focused on the inclusion of a luminescent osmium complex into the MOF scaffold. …

Extending Single Entity Electrochemistry Towards The Detection Of Single Bacteria In Micro Volumes, Ashley Tubbs, Junaid Ahmed, Julio C. Alvarez

Graduate Research Posters

Single entity electrochemistry (SEE) is an emerging electroanalytical technique with the ability to push the limit of detection of electrochemical sensors to the single particle level. It measures the change in current over time, making SEE rapid, simple, and cost-effective. The type of current response observed in the scan can provide information about the physiochemical processes underlying the signal. While SEE was originally developed to detect single molecules and nanoparticles, it has been widely applied to micron-sized particles, including emulsion droplets, bacteria, viruses, and mammalian cells. Some recent advances in this technique have focused on the detection of microscopic quantities …

Improvement In 14-3-3 Binding Site Prediction, Katherine K. Mccormack

ScholarsArchive Data

The 14-3-3 family of phospho-binding proteins regulate a variety of major cellular processes through interaction with a network of dynamic proteins. Deregulation of the 14-3-3 interaction network contributes to a variety of degenerative disorders and cancers. Our lab focuses on identifying novel 14-3-3 interactions and understanding how 14-3-3 binding regulates protein function. A major gap in this process is that identifying the phospho-site where 14-3-3 docks on a given protein is time- and resource-consuming. Prediction algorithms have been developed to predict canonical 14-3-3 binding sites, however, there are many non-canonical sites that existing software is unable to predict. To fill …