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Full-Text Articles in Chemistry

Combination Nanomedicines For Cancer Therapy, Noureen Siraj Mar 2024

Combination Nanomedicines For Cancer Therapy, Noureen Siraj

Arkansas Women in STEM Conference

Nanomedicines derived from combination ionic nanomaterials (INMs) offer synergistic therapy for effective treatment of cancer. This approach addresses the limitations of conventional treatment options and offers active targeting of tumors due to EPR effect


Study Of Solvent-Free, Microwave-Assisted Ring-Opening Reactions Of Phenyl Glycidyl Ether With Azoles, Marygrace Mcafee, Joshua Pack, Brian Walker Mar 2024

Study Of Solvent-Free, Microwave-Assisted Ring-Opening Reactions Of Phenyl Glycidyl Ether With Azoles, Marygrace Mcafee, Joshua Pack, Brian Walker

Arkansas Women in STEM Conference

Literature precedent supports that microwave-assisted organic synthesis can afford fast, high-yield, and efficient synthetic pathways, often comparable to or better than traditional heating methods. Building on this, our work utilizes microwave-assisted synthesis for the epoxide ring opening of phenyl glycidyl ether through nucleophilic addition, aiming to create both pyrazole and imidazole derivatives. These heterocyclic azole compounds have been shown to be important due to their presence in many natural products, as well as their anti-fungal and other pharmacological activities. We are exploring the use of microwave irradiation under neat (solvent-free) conditions, focused on a streamlined approach to minimize time, energy …


Women In Stem Conference, Maryann Rettig, Sara E. Hubbard Ph.D Mar 2024

Women In Stem Conference, Maryann Rettig, Sara E. Hubbard Ph.D

Arkansas Women in STEM Conference

Analysis of BPA Leaching from Feminine Hygiene Products into Simulated Vaginal Fluid using Fluorescence Spectrophotometry

Maryann Rettig and Sara E. Hubbard, Ph.D.

Bisphenol-A (BPA) is a chemical compound commonly used to produce several plastics and epoxy resins. Recently, BPA has also been detected in feminine hygiene products. Because of a structural resemblance to estradiol, BPA can act as an endocrine disruptor, which has linked BPA to several health complications such as cancer development, reduced fertility, and early puberty. In recent summer research at Ouachita Baptist University, it was determined that fluorescence spectrophotometry could be used to monitor BPA leaching over …