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Full-Text Articles in Chemistry
Functionalizing Titanium Implants With Bioactive Peptides To Increase Osseointegration, Neil Bernard
Functionalizing Titanium Implants With Bioactive Peptides To Increase Osseointegration, Neil Bernard
Williams Honors College, Honors Research Projects
Orthopedic surgeries have continued to increase, but the material of choice remains constant: titanium. Titanium has become the benchmark implant material due to its durability and non-immunogenic properties. However, while high rates of success are correlated with joint replacement surgery, certain patients with predisposed diseases such as diabetes or arthritis may have increased complications.1 This can be due to lack of osseointegration due to decreased bone formation and mineralization,2 which will lead to increased rates of infection or aseptic loosening of the implant from the bone. 3 Current methods to alleviate these complications include invasive revisional surgeries, which …
Multi-Dimensional Mass Spectrometry For The Characterization Of Glycopolymers, Maria Ganios
Multi-Dimensional Mass Spectrometry For The Characterization Of Glycopolymers, Maria Ganios
Williams Honors College, Honors Research Projects
Several glycopolymers synthesized by Activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP), were characterized by mass spectrometry to elucidate their microstructure and architecture. Analyses were performed using Matrix Assisted Laser Desorption Ionization- Time of Flight/ Time of Flight (MALDI-ToF/ToF) and Electrospray Ionization Mass Spectrometry (ESI-MS) instruments. The linear isopropylidenated glycopolymer (P65B1) analyzed with ESI-MS also was examined with multi-stage mass spectrometry (MSn) using collision induced dissociation (CID) to examine the tetramer parent ion. This glycopolymer was found to be either cyclic or linear (sans end groups) due to the data being fit for both forms …