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Exploring The Mechanism Of The Electrostatic Denaturation Of Double-Stranded Dna, Gayatri Raghu
Exploring The Mechanism Of The Electrostatic Denaturation Of Double-Stranded Dna, Gayatri Raghu
Master's Theses
Electrostatic melting is an electrochemical tool that can be used to analyze the stability of DNA, allowing for the detection of various mutations in double-stranded DNA (dsDNA). Here, we explore the influence of electrostatic double layer formation on the unzipping of dsDNA to better comprehend the mechanism of this process. Previous studies by our lab show that the melting curve produced can distinguish between fully complementary 34-bp strands and a version of the same sequence in which one base pair has been replaced with a mismatch pair or detect and characterize the crosslinking of the dsDNA by anticancer drug cisplatin. …