Chemistry Commons^™

Effective And Selective Dna Modification On Bacterial Membranes, Qian Tian, Yousef Bagheri, Puspam Keshri, Rigumula Wu, Kewei Ren, Qikun Yu, Mingxu You

Chemistry Department Faculty Publication Series

With highly precise self-assembly and programmability, DNA has been widely used as a versatile material in nanotechnology and synthetic biology. Recently, DNA-based nanostructures and devices have been engineered onto eukaryotic cell membranes for various exciting applications in the detection and regulation of cell functions. While in contrast, the potential of applying DNA nanotechnology for bacterial membrane studies is still largely underexplored, which is mainly due to the lack of tools to modify DNA on bacterial membranes. Herein, using lipid-DNA conjugates, we have developed a simple, fast, and highly efficient system to engineer bacterial membranes with designer DNA molecules. We have …