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Full-Text Articles in Chemistry
Reactivity Of Acyclic (Pentadienyl)Iron(1+) Cations: Synthetic Studies Directed Toward The Frondosins, Do W. Lee, Rajesh K. Pandey, Sergey Lindeman, William Donaldson
Reactivity Of Acyclic (Pentadienyl)Iron(1+) Cations: Synthetic Studies Directed Toward The Frondosins, Do W. Lee, Rajesh K. Pandey, Sergey Lindeman, William Donaldson
Chemistry Faculty Research and Publications
A short, 4-step route to the scaffold of frondosin A and B is reported. The [1-methoxycarbonyl-5-(2′,5′-dimethoxyphenyl)pentadienyl]Fe(CO)3+ cation was prepared in two steps from (methyl 6-oxo-2,4-hexadienoate)Fe(CO)3. Reaction of this cation with isopropenyl Grignard or cyclohexenyllithium reagents affords (2-alkenyl-5-aryl-1-methoxycarbonyl-3-pentene-1,5-diyl)Fe(CO)3 along with other addition products. Oxidative decomplexation of these (pentenediyl)iron complexes, utilizing CuCl2, affords 6-aryl-3-methoxycarbonyl-1,4-cycloheptadienes via the presumed intermediacy of a cis-divinylcyclopropane.
Design And Syntheses Of Fluorescent Cytosine Analogues, David W. Dodd
Design And Syntheses Of Fluorescent Cytosine Analogues, David W. Dodd
Electronic Thesis and Dissertation Repository
The avid hybridization of peptide nucleic acid (PNA) to DNA and RNA along with the molecule’s biological stability has led it to be used in both antisense and antigene capacities. PNA acts against translation via a steric blockade mechanism. It is therefore reasonable to assume that increased heteroduplex stability could lead to increased potency. Two ways of doing this were explored. I) N-Terminal attachment of a platinous chloride chelating moiety to PNA complementary to Xenopus noggin was synthesized with the objective of selective, covalent platination of the target transcript in vivo. Phenotypes consistent with knockdown of the selected …
Synthesis Of Hydroxy- And Polyhydroxy-Substituted 1,3-Diaminocyclohexanes, Anobick Sar, Sergey Lindeman, William Donaldson
Synthesis Of Hydroxy- And Polyhydroxy-Substituted 1,3-Diaminocyclohexanes, Anobick Sar, Sergey Lindeman, William Donaldson
Chemistry Faculty Research and Publications
The synthesis of hydroxy-trans-1,3-diaminocyclohexanes based on nitroso-Diels-Alder cycloaddition of (cyclohexadienyl)phthalimide is reported.
New Synthetic Methodologies Directed Toward Pharmacologically Active Compounds As Well As Silole Based Chromophores For Analytical And Optoelectronic Applications, Mahmoud M. Abd Rabo Moustafa
New Synthetic Methodologies Directed Toward Pharmacologically Active Compounds As Well As Silole Based Chromophores For Analytical And Optoelectronic Applications, Mahmoud M. Abd Rabo Moustafa
Electronic Thesis and Dissertation Repository
The development of new and efficient synthetic methodologies to prepare heterocyclic compounds has received great attention over the years due to their importance in the pharmaceuticals and fine chemicals industries. Described herein are several novel syntheses of a variety of heterocycles including siloles, azaindoles, piperideines, piperidines and tetrahydropyrans.
A one-pot, two-step methodology involving Tamao’s reductive cyclization followed by Negishi cross coupling was utilized to synthesize several new series of silole-based chromophores. The property studies revealed new electropolymerized poly(thienyl-silole)s with enhanced photoefficiency for all-polymer solar cells. In addition, a new procedure is developed for the synthesis of the first dissymmetric silole …