Chemistry Commons^™

Development And Application Of A Gg-Irms Reductive Pyrolysis Reactor Interface For The Δ34S Determination Of Sulfur In Individual Organic Compounds, N. Deborah Hewlett

Chemistry & Biochemistry Theses & Dissertations

The incorporation of sulfur into sedimentary organic matter is an important aspect of organic carbon preservation. A better understanding of the sulfur cycle and the formation of organo-sulfur compounds are necessary if we are to better understand the interaction of biogeochemical cycles of C, N, O, H. and S. Currently, the determination of ³⁴S/³²S in organic matter is limited to bulk organic samples. The sulfur isotopic analysis of individual organo-sulfur compounds within the sediments should allow for a more complete understanding of the sulfur cycle and the processes which lead to sulfur incorporation into organic matter. This …

Cell Toxicity And Uptake Of Rrr-Alpha-Tocopheryl Polyethylene Glycol 1000 Succinate (Tpgs) By Various Cell Ines In Vitro., Christelle Komguem Kamga

Electronic Theses and Dissertations

This research focused on investigating and comparing the cytotoxicity and cellular uptake of RRR-alpha-tocopheryl polyethylene glycol succinate (TPGS, with that of alpha-tocopheryl succinate (α-TS). Both TPGS and α-TS are water-soluble forms of vitamin E with important clinical applications. Cytotoxicity assays with RAW 264.7 and LNCaP cells incubated overnight with TPGS or α-TS at concentrations ≥ 12.4 μM suggest that α-TS is more cytotoxic than TPGS. Macrophages were found to be more sensitive than LNCaP cells when treated with similar concentrations of α-TS. For both cell lines, most of the TPGS or α-TS taken up remained esterified after 24 hours. Our …

Cell Toxicology Study Of Rrr-Alpha-Tocopheryl Polyethylene Glycol 1000 Succinate (Tpgs)., Clarisse Sornsay Muenyi

Electronic Theses and Dissertations

This research focused on the cytotoxic properties of RRR-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) in transformed and cancerous cell lines. We used RAW264.7 macrophage and prostate cancer (LNCaP) cell lines in this study. TPGS caused cell death and decreased cell viability in a dose and time dependent manner. Cell death was evaluated fluorimetrically by employing the nucleic acid-binding fluorophore; propidium iodide. A colorimetric 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay was used to evaluate cell viability. Cell death can occur through necrosis or apoptosis. Our results suggested that TPGS triggered apoptotic cell death. Induction of apoptosis, as measured by caspase …

Aldol Reactions: E-Enolates And Anti-Selectivity, Matthew Grant Anderson

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

A common structural motif in complicated natural product molecules is an alkyl group at an alpha position to a carbonyl and an alcohol at the beta position anti to each other. This arrangement occurs in bioactive molecules that are important for medical research such as spongistatin A at the C15-C16 position and in (-)-baconipyrone C at C12-C13. Bioactive molecules such as these generally occur in such a low concentration in the organism in which they originate that deriving them from the natural source for research is not practical so efficient syntheses are sought. Reactions that produce 1,2 syn aldol products …

Synthesis Of Novel Alkaline Earth Metal Acetylides, Eva Baker

Honors Capstone Projects - All

Acetylide complexes of the heavy alkaline-earth metals were first introduced by our group. With our group being interested in how the ligand and donor affect the structural chemistry of the resulting complexes, my project was focused on the detailed analysis of past work and the extension towards new ligand and donor sets. The work required the analysis and development of synthetic procedures towards these highly reactive species.

Past synthetic work in our group had established several synthetic routes towards the target compounds including transamination and toluene elimination. Using toluene elimination, I was able to reproduce the synthesis of M(C≡CSiPh_{3 …}

Structural Study Of Disease Related Proteins, Ayse Sinem Ozyurt

Electronic Theses and Dissertations

The availability of complete sequences for the genomes of many organisms changes the researcher's attention from genome sequencing to finding the function of gene products, the proteins. The three dimensional (3D) structure of a protein is helpful to understand its function, because tertiary structure is more conserved in evolution than sequence. The 3D structures can be found quickly by using high-throughput (HT) methods for protein expression, purification, characterization and structure determination. This process is very challenging in every step. Therefore we selected nearly 200 cancer related proteins as targets to see the difficulties in trying to determine the web predicted …

Synthesis Of Novel Porphyrazines And Binding Studies To Dna Quadruplexes, Carlos Ramirez

Seton Hall University Dissertations and Theses (ETDs)

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