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Full-Text Articles in Chemistry
Synthesis And Characterization Of New Azo Dyes Derived From Acyclovir And Sulfamethoxazole And Study Their Biological Activity, Abdul Rahman Y. Wahoud, Thanaa Shriteh, Ali Yousef, Mohammad Mazen Kondakji
Synthesis And Characterization Of New Azo Dyes Derived From Acyclovir And Sulfamethoxazole And Study Their Biological Activity, Abdul Rahman Y. Wahoud, Thanaa Shriteh, Ali Yousef, Mohammad Mazen Kondakji
Hadhramout University Journal of Natural & Applied Sciences
In this research, two new azo dyes, 9-(2-Hydroxy-ethoxymethyl)-2-(2-hydroxy5nitrophenylazo)-1,9-dihydro-purin-6-one and 4-(2-Hydroxy-napHthalen-1-ylazo)-N-(5-methyl-isoxazol-3-yl)-benzenesulfonamide, derived from Acyclovir and Sulfamethoxazole was synthesized. The first dye synthesis was started by diazation of acyclovir, then combined with 4-nitrophenol activated with potassium hydroxide 10%, yielding 80%, and its purity was verified by thin layer chromatography (TLC). The second dye synthesis was started by diazation of Sulfamethoxazole then combined with β-naphthol activated with potassium hydroxide 10%, yielding 87%, and its purity was verified by thin layer chromatography (TLC). The identity of the resulting pigments was determined based on spectroscopic methods such as infrared spectroscopy, proton nuclear magnetic resonance spectrum …
Amidoalkylation Of Aromatic Compounds, Mukhabbat Yuldasheva, Khurshida Turaeva, Tursunali Kholiqov
Amidoalkylation Of Aromatic Compounds, Mukhabbat Yuldasheva, Khurshida Turaeva, Tursunali Kholiqov
Bulletin of National University of Uzbekistan: Mathematics and Natural Sciences
As the result of systematical investigation of amidomethylation reaction benzene, toluene, isomeric xylenes, benzodioxane-1,4, mono- and dimethyl ethers of resorcinole, dimethyl ethers of hydroquinone with methylol and ethylol derivatives amides and imides, acetonitrile, benzonitrile and paraform the amidomethyl derivatives have been obtained and also influence of different factors on their yields and direction of investigated reactions was determined. Synthesis of amidomethyl derivatives of aromatic hydrocarbons, ethers dihydricpenols and most probable reaction mechanism was proposed.