Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Chemistry
Influence Of Conformational Restriction On The Antibacterial Activity And Ribosomal Selectivity Of Aminoglycoside Antibiotics, Michael Gabriel Pirrone
Influence Of Conformational Restriction On The Antibacterial Activity And Ribosomal Selectivity Of Aminoglycoside Antibiotics, Michael Gabriel Pirrone
Wayne State University Dissertations
The ever-increasing threat posed by multidrug-resistant infectious bacteria necessitates
the development of novel antibiotics. Aminoglycoside antibiotics are growing in interest due to
their broad spectrum of activity, lack of known drug related allergies, low manufacturing cost,
and their well-studied mechanism of action. The simplification of rational drug design due to the
well-studied mechanism of action is the key to overcoming the issues presented by these drugs,
namely ototoxicity and nephrotoxicity.
A study of the effect of the conformation of the aminoglycoside ring I side chain is
described wherein it was discovered that an increase in a particular conformation augments the …