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Full-Text Articles in Chemistry

Phosphatidylinositol 3,4,5–Trisphosphate Probe Synthesis And Microarray Protein Binding Studies To Investigate Multivalency And Detect Proteins Upregulated In Cancer, Benjamin Michael Smith Aug 2013

Phosphatidylinositol 3,4,5–Trisphosphate Probe Synthesis And Microarray Protein Binding Studies To Investigate Multivalency And Detect Proteins Upregulated In Cancer, Benjamin Michael Smith

Masters Theses

Protein–lipid binding interactions control many processes at the cellular level. Many of these biological events between proteins and lipids are often associated with signaling pathway diseases such as cancer and diabetes. Therefore, increasing our knowledge of protein–lipid binding interactions will provide a better understanding of the signaling pathways of living systems. Pursuing this further, the phosphatidylinositol polyphosphates (PIPs) are an important family of signaling lipids that control key biological processes. Thus, the work described in this thesis was aimed at developing methods to validate these types of lipid–protein binding interactions. The goals of these projects were to synthesize the PIP …


Using Soil Organic Matter As An Iron Chelate To Enhance The Efficiency Of Modified Fenton Oxidition Of Diesel Fuel In Arctic Soils, Mary K. Sherwood Aug 2013

Using Soil Organic Matter As An Iron Chelate To Enhance The Efficiency Of Modified Fenton Oxidition Of Diesel Fuel In Arctic Soils, Mary K. Sherwood

Masters Theses

Laboratory experiments were conducted to investigate the use of modified fenton chemistry on the treatment of three soils from the Canadian arctic, all with abundant soil organic matter, iron and manganese oxides, and diesel fuel contamination. The purpose of these studies was to (I) to assess modified fenton chemistry as a treatment option for petroleum-contaminated arctic soils, and (2) to evaluate the impact of soil organic matter on the modified fenton treatment of soils. Modified fenton treatment was compared for reactions in which ethylenediaminetetraacetate was added as a chelate vs. reactions in which the native soil organic matter was the …