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Insight Into The Inhibition Of Ribonucleotide Reductases By 2'-Chloro-2'-Deoxynucleotides And 2'-Azido-2'-Deoxynucleotides: Biomimetic Studies With Model Substrates, Mukesh M. Mudgal Dr.
Insight Into The Inhibition Of Ribonucleotide Reductases By 2'-Chloro-2'-Deoxynucleotides And 2'-Azido-2'-Deoxynucleotides: Biomimetic Studies With Model Substrates, Mukesh M. Mudgal Dr.
FIU Electronic Theses and Dissertations
Ribonucleotide Reductases (RNRs) are crucial enzymes that catalyze reduction of ribonucleotides to deoxyribonucleotides, required for the biosynthesis of DNA. Vital role played by RNR in the biosynthesis of DNA and its control on cell growth made it one of the main targets for anticancer therapy. Several laboratories clarified the aspects of reaction cascades at active site of RNR. Biochemical studies of RNR by Stubbe for the inactivation of RDPR by 2'-chloro-2'-deoxyuridine-5'-diphosphate emphasizes departure of chlorine as an anion, while biomimetic studies by Robins with 6'-O-nitro-2'-chloro-homonucleosides emphasizes the elimination of chlorine substituent from 2'-position as a radical. To clarify …