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Full-Text Articles in Chemistry
Biomimetic Modeling Of The Nitrogen-Centered Radical Postulated To Occur During The Inhibition Of Ribonucleotide Reductases By 2'-Azido-2'-Deoxynucleotides., Thao P. Dang
FIU Electronic Theses and Dissertations
Ribonucleotide reductases (RNR) are essential enzymes that catalyze the reduction of ribonucleotides to 2'-deoxyribonucleotides, which is a critical step that produces precursors for DNA replication and repair. The inactivation of RNR, logically, would discontinue producing the precursors of the DNA of viral or cancer cells, which then would consequently end the cycle of DNA replication. Among different compounds that were found to be inhibitors of RNR, 2'-azido-2'-deoxynucleotide diphosphates (N3NDPs) have been investigated in depth as potent inhibitors of RNR. Decades of investigation has suggested that the inactivation of RNR by N3NDPs is a result of the formation of a nitrogen-centered …
Developing Of Germyldesulonylation And Thiodesulfonylation Reactions For The Synthesis Of Novel Nucleoside Analogues. Efficient Synthesis Of Novel (Α-Fluoro)Vinyl Sulfides, Pablo R. Sacasa Jr
Developing Of Germyldesulonylation And Thiodesulfonylation Reactions For The Synthesis Of Novel Nucleoside Analogues. Efficient Synthesis Of Novel (Α-Fluoro)Vinyl Sulfides, Pablo R. Sacasa Jr
FIU Electronic Theses and Dissertations
S-adenosyl-L-homocysteine (AdoHcy) hydrolase effects hydrolytic cleavage of AdoHcy to produce both adenosine and L-homocysteine and is a feedback inhibitor of S-adenosyl-L-methionine (SAM). Nucleoside analogues bearing an alkenyl or fluoroalkenyl chain between sulfur and C5′ utilizing Negishi coupling reactions were synthesized. Palladium-catalyzed cross-coupling between the 5′-deoxy-5′-(iodomethylene) nucleosides and alkylzinc bromides gives analogues with the alkenyl unit. Palladium-catalyzed selective monoalkylation of 5′-(bromofluoromethylene)-5′-deoxy-adenosine with alkylzinc bromide afford adenosylhomocysteine analogues with a 6′-(fluoro)vinyl motif. The vinylic adenine nucleosides produced time-dependent inactivation of the S-adenosyl-L-homocysteine hydrolases. Stannydesulfonylation reaction is a critical step in the synthesis of E-fluorovinyl cytidine (Tezacitabine) a ribonucleoside reductase inhibitor with a …