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Full-Text Articles in Chemistry
Phosphatase Enzyme-Responsive Synthetic Lipids For Liposome Immolation Towards Enhanced Cargo Release, Justin Thomas Kirby
Phosphatase Enzyme-Responsive Synthetic Lipids For Liposome Immolation Towards Enhanced Cargo Release, Justin Thomas Kirby
Masters Theses
Liposomal nanoscale delivery vehicles have been shown to aid in the delivery of therapeutic cargo due to their ability to encapsulate and improve the pharmacokinetic properties of a range of drug molecules. However, liposome therapeutic potential could be enhanced by exerting greater control over liposome cargo delivery and release. This is being pursued by designing lipids that are able to respond to specific stimuli, particularly those overexpressed in diseased cells. In this thesis, we describe stimuli-responsive liposomes in which the enzyme alkaline phosphatase is used as the stimulus. This trigger was selected since this enzyme is overexpressed in certain cancer …
Design And Synthesis Of Lipid Probes Used For Membrane Derivatization And Fusion, Stuart Allen Whitehead
Design And Synthesis Of Lipid Probes Used For Membrane Derivatization And Fusion, Stuart Allen Whitehead
Doctoral Dissertations
Lipids control a variety of complex biological processes. Bulk lipids such as phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylethanolamine (PE) represent the major components of cellular membranes. In addition, unilamellar vesicles composed of lipids (liposomes) are valuable for delivery applications since they can encapsulate and transport drugs and other agents. In order to maximize delivery efficiency and target specific membranes, the ability to trigger and control vesicle-vesicle fusion is desirable. Such approaches generally seek to mimic the membrane fusion machinery present in nature while imparting specificity in the membranes that undergo fusion. The goal of this work is selective drug delivery …
Developing Synthetic Methods To Prepare Discrete Metal-Organic Nanotubes, Derek L. Mull
Developing Synthetic Methods To Prepare Discrete Metal-Organic Nanotubes, Derek L. Mull
Masters Theses
Metal-organic nanotubes (MONTs) are an emerging class of discrete materials that are the 1D variant of metal-organic frameworks (MOFs). MONTs have potential to become an alternative 1D material to carbon nanotubes, metal oxide nanotubes, and boron nitride nanotubes because they possess an organic ligand that can be functionalized and tuned for specific applications. Despite this potential, only a handful of structures have been reported and only two examples of discrete MONTs exist in the literature. It is thus imperative to develop general methods to prepare and characterize discrete MONTs to bring them to the forefront of the scientific literature.
Efforts …
Synthesis Of Isotopologues And Nanoparticles For Hyper Raman Spectroscopy, Burton K. Mandrell
Synthesis Of Isotopologues And Nanoparticles For Hyper Raman Spectroscopy, Burton K. Mandrell
Chancellor’s Honors Program Projects
No abstract provided.