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Stereoselective Synthesis Of Pseudosaccharide Derivative And Bisphosphoramidate Core Of Em2487, Saad Z. Mohammed Ali

Electronic Theses and Dissertations

HIV is among the leading causes of death worldwide resulting in over 1 million deaths annually according to the World Health Organization. Despite advances in the treatment of HIV, eradicating this pathogen remains a top priority in the medical and scientific communities. EM2487 is a natural product produced by Streptomyces sp. Mer-2487 that possesses promising activity against HIV. Specifically, EM2487 is a potent and selective inhibitor of HIV replication in both acutely and chronically infected cells. The observed HIV activity is hypothesized to be the result of targeting the Tat-TAR (trans-activation response) element which activates RNA polymerase II at the …