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Full-Text Articles in Chemistry
Selective Indicators For Optical Determination Of Disease Biomarkers, Lovemore Hakuna
Selective Indicators For Optical Determination Of Disease Biomarkers, Lovemore Hakuna
Dissertations and Theses
The most abundant biological thiols, homocysteine (Hcy), cysteine (Cys) and glutathione (GSH) have been the subject of intense research due to their association with a wide range of diseases. They play a key role in maintaining the redox status of biological systems. Selective detection methods for these thiols are challenging due to their similar structures and properties. Current commercially available detection methods use separations, fragile and expensive enzymatic or immunogenic materials and complex instrumentation. This has led to a global effort towards developing simple and inexpensive optical probes and indicators selective for specific biological thiols.
Highly selective chemical probes and …
Characterization Of Methylene Diphenyl Diisocyanate Protein Conjugates, Morgen Mhike
Characterization Of Methylene Diphenyl Diisocyanate Protein Conjugates, Morgen Mhike
Dissertations and Theses
Diisocyanates (dNCO) such as methylene diphenyl diisocyanate (MDI) are used primarily as cross-linking agents in the production of polyurethane products such as paints, elastomers, coatings and adhesives, and are the most frequently reported cause of chemically induced immunologic sensitization and occupational asthma (OA). Immune mediated hypersensitivity reactions to dNCOs include allergic rhinitis, asthma, hypersensitivity pneumonitis and allergic contact dermatitis.
There is currently no simple diagnosis for the identification of dNCO asthma due to the variability of symptoms and uncertainty regarding the underlying mechanisms. Immunological sensitization due to dNCO exposure is traditionally thought to require initial conjugation of the dNCO to …