Chemistry Commons^™

Fluorinated Metallo Phthalocyanines For Chemical And Biological Catalysis, Hemantbhai H. Patel

Seton Hall University Dissertations and Theses (ETDs)

The rational design of robust oxidation catalysts based on organic molecules is hindered by the presence of labile C-H bonds. We have shown recently that replacing all C-H bonds by a combination of fluoro- and perfluoro-groups in a bioinspired Cytochrome P450 model based on a phthalocyanine, Pc, scaffold results in a stable yet reactive oxidation catalyst. The Pc cobalt complex catalyzes, for example, the aerobic oxidation of thiols to disulfides, a reaction of both biological significance and industrial importance.

The presence of robust C-F bonds, however, renders the catalyst unsuitable for attachment to solid-state supports, except via van der Waals …

Quechers (Quick, Easy, Cheap, Effective, Rugged, And Safe) Extraction – Gas Chromatography For The Analysis Of Drugs, Michelle L. Schmidt

Seton Hall University Dissertations and Theses (ETDs)

QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) is an extraction technique developed by Anastassiades and co-workers initially for the extraction of veterinary drugs from animal tissue. Since its inception, it was discovered that this method is particularly adept for the extraction of polar and basic compounds, thus the majority of research previously performed using QuEChERS involves the extraction of pesticides from various matrices, especially fruits, vegetables, and other food products. Combining a liquid-liquid extraction (LLE) and a dispersive solid phase extraction (d-SPE) clean up, QuEChERS provides a clean sample for analysis by gas chromatography (GC) or liquid chromatography (LC) …

Monitoring Dissolution Of Nonsteroidal Anti-Inflammatory Drugs Using Infrared Spectroscopy, Julianne Berger

Seton Hall University Dissertations and Theses (ETDs)

A comparison study was conducted to look at the formulation of three brands of naproxen sodium. These brands included Bayer Aleve ®, CVS All Day Pain Relief and Walgreens All Day Pain Relief. The active and inactive ingredients were the same yet the size and shape of the tablets differ among the three brands. S-naproxen was extracted from the tablets and evaluated by GC-MS to determine the purity of naproxen in the tablets. Dissolution was monitored by an IR probe for eight hours while using 0.1M phosphate buffer pH 7.4, 0.05M phosphate buffer pH 4.5 and simulated gastric fluid pH …