Chemistry Commons^™

Incorporation Of Fluorine Into Peptides And One-Bead One-Compound Libraries Through Copper-Free Click Chemistry For The Discovery Of Radiopharmaceuticals, Emily M. Murrell

Electronic Thesis and Dissertation Repository

Molecular imaging is making possible the understanding of intricate biological processes in real-time in both healthy and diseased tissues. The ability to non-invasively locate biomarkers of disease with good sensitivity and specificity affords the ability to provide accurate and early diagnoses, and patient stratification for therapy. The chemokine receptor CXCR4 is one biomarker of interest, as it is overexpressed in many cancers, yet has low expression elsewhere in normal physiology. This thesis will document a method of combinatorial chemistry to construct libraries of new potential peptide-based imaging agents for positron emission tomography (PET) imaging. It will also incorporate the study …