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Full-Text Articles in Chemistry
Interaction Of Pharmaceutical Compounds With Dissolved Organic Matter, Carlen Nigl Smith
Interaction Of Pharmaceutical Compounds With Dissolved Organic Matter, Carlen Nigl Smith
Honors Theses
Highly prescribed pharmaceutical compounds and their metabolites used to treat conditions ranging from infections to depression are of environmental concern as these excreted compounds are increasingly appearing in wastewater influent. As pharmaceuticals enter treatment plants they also can interact with dissolved organic matter (DOM) present. This potential interaction between pharmaceutical compounds and DOM may inhibit the advanced oxidation process (AOP) based removal of drugs during water treatment. The focus of this research was to utilize multinuclear magnetic resonance and hydroxyl radical kinetics to assess whether an interaction between influent pharmaceuticals and DOM does occur, the extent of the interaction, and …
A Method For The Determination Of Purity Of Pnu-10483 Bulk Drug By Capillary Zone Electrophoresis, Gavin Gibson
A Method For The Determination Of Purity Of Pnu-10483 Bulk Drug By Capillary Zone Electrophoresis, Gavin Gibson
Honors Theses
In this investigation, a method was developed for the determination of purity of the drug PNU-10483 using the technique of capillary zone electrophoresis (CZE). CZE was seen as a potential alternative to the formerly used procedure of ion-pair reversed phase highperformance liquid chromatography (HPLC). Nearly five years earlier, a similar study was performed, in which an attempt was made to develop a method that used CZE to determine the purity of bulk drug and the potency of drug tablets. While this development was mostly successful, sporadically unpredictable results reduced the method's overall viability. These outliers were thought to be caused …
Sds Non-Acrylamide Polymeric Gel-Filled Capillary Electrophoresis For Molecular Size Separation Of Protein, Devon Andres
Sds Non-Acrylamide Polymeric Gel-Filled Capillary Electrophoresis For Molecular Size Separation Of Protein, Devon Andres
Honors Theses
Sodium dodecyl sulfide (SDS) non-acrylamide gel-filled capillary columns are a new technology being used for analysis and separation of biotechnology-derived proteins. This research was to compare this new technology to the current methods of SDS polyacrylamide gel electrophoresis (SDS-PAGE) and high-performance size-exclusion chromatography (HPSEC). The molecular mass of four different recombinant proteins were determined by two commercialized SDS non-acrylamide gel-filled capillary columns, SDS-PAGE, and HPSEC. The data obtained showed that the SDS non-acrylamide gel-filled capillary columns were compatible with the SDS-PAGE technique for molecular mass determination. HPSEC was shown to be unreliable for molecular weight determination. SDS non-acrylamide gel-filled capillary …