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Full-Text Articles in Chemistry
Y-Aminobutyric Acid Inhibits Synergistic Interleukin-6 Release And Increases Intracellular Cytokine Content In C6 Astrocytoma Cells In Vitro, Daniella Sandoval, Becky M. Hess, Bryan L. Spangelo
Y-Aminobutyric Acid Inhibits Synergistic Interleukin-6 Release And Increases Intracellular Cytokine Content In C6 Astrocytoma Cells In Vitro, Daniella Sandoval, Becky M. Hess, Bryan L. Spangelo
Undergraduate Research Opportunities Program (UROP)
Alzheimer’s disease (AD) is a neurodegenerative disorder that is characterized by memory loss and is the most common cause of dementia. It is has been hypothesized that pro-inflammatory cytokines induce the inflammation that is believed to be the cause of the neuronal death that is associated with AD. γ-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the Central Nervous System possessing membrane hyperpolarization or depolarization activities. A decline in GABA may enhance cytokine release in Alzheimer’s disease resulting in neuroinflammation. Therefore, we investigated the GABA-mediated suppression of the synergistic release of interleukin-6 (IL-6) induced by interleukin 1- (IL-1) and …
Synthesis Of Novel Aromatic Quinols For Colon And Renal Cancers, Bradley J. Davey, Tae Soo Jo, Pradip K. Bhowmik
Synthesis Of Novel Aromatic Quinols For Colon And Renal Cancers, Bradley J. Davey, Tae Soo Jo, Pradip K. Bhowmik
Undergraduate Research Opportunities Program (UROP)
Colon Cancer: The third most common cancer in USA. More than 1 million Americans currently living with colon cancer. 148,810 new cases expected in 2010. 50,000 deaths annually.
Renal Cancer: Approximately 58,000 people diagnosed in USA annually. Seventh most common cancer and tenth most common cause of cancer related death in men.
Aromatic quinols have demonstrated in vitro antitumor activity. Three heteroaromatic quinols show antitumor activity.