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The Synthesis Of Chemosensors For Toxic Analytes, Johnathan Hugh Broome
The Synthesis Of Chemosensors For Toxic Analytes, Johnathan Hugh Broome
Dissertations
A number of chemosensors have been designed and synthesized to target cations (Zn2+ions), neutral molecules (cathinones), charged molecules (aminoindanes), and anions. The Zn2+ ion sensor featured bistriazole designed binding unit and ferrocene signaling units. Characterization of Zn2+ ion binding was carried out with electrochemical techniques (CV and DPV), 1H-NMR, mass spectrometry, and molecular modelling. It exhibited a 1:1 binding stoichiometry with Zn2+ and had an affinity for ZnCl2 (Log K1:1 = 4.1 ± 0.02) over other Zn2+ salts.
The cathinone probe was designed to selectively bind mephedrone over common street drugs …
Molecular Probes For The Detection Of Zn2+ And Fe3+ Ions, Erendra Manandhar
Molecular Probes For The Detection Of Zn2+ And Fe3+ Ions, Erendra Manandhar
Dissertations
A number of molecular probes have been designed and synthesized for the detection of Zn2+ and Fe3+ ions. Two types of functional groups have been incorporated into the molecular scaffolds to utilize different fluorescent mechanisms. The first class of receptors contains a pyrene moiety. These molecular probes use the excimer mechanism for the detection of Zn2+ ion. The probes work well in an organic solvent with a detection limit of 20 nM (one ppb). Alternatives are made to make them water soluble, but this proved to be difficult. An interesting ion-induced self-assembly system will also be discussed. …