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Full-Text Articles in Chemistry
G-Ruption: The Third International Meeting On G-Quadruplex And G-Assembly, Liliya A. Yatsunyk, T. M. Bryan, F. B. Johnson
G-Ruption: The Third International Meeting On G-Quadruplex And G-Assembly, Liliya A. Yatsunyk, T. M. Bryan, F. B. Johnson
Chemistry & Biochemistry Faculty Works
A three and a half day conference focusing on nucleic acid structures called G-quadruplexes (G4s) and other guanine-based assemblies was held in Sorrento. Italy (June 28-July 1, 2011) and featured 35 invited talks and over 89 posters. The G-quadruplex field continues to expand at an explosive rate with the emergence of new connections to biology, chemistry, physics, and nanotechnology. Following the trend established by the previous two international G4 meetings, the conference touched upon all these areas and facilitated productive exchanges of ideas between researchers from all over the world.
Interaction Of Human Telomeric Dna With N-Methyl Mesoporphyrin Ix, John Michael Nicoludis , '12, Steven Paul Barrett , '13, J.-L. Mergny, Liliya A. Yatsunyk
Interaction Of Human Telomeric Dna With N-Methyl Mesoporphyrin Ix, John Michael Nicoludis , '12, Steven Paul Barrett , '13, J.-L. Mergny, Liliya A. Yatsunyk
Chemistry & Biochemistry Faculty Works
The remarkable selectivity of N-methyl mesoporphyrin IX (NMM) for G-quadruplexes (GQs) is long known, however its ability to stabilize and bind GQs has not been investigated in detail. Through the use of circular dichroism, UV-visible spectroscopy and fluorescence resonance energy transfer (FRET) melting assay we have shown that NMM stabilizes human telomeric DNA dAG(3)(TTAG(3))(3) (Tel22) and is selective for its parallel conformation to which it binds in 1:1 stoichiometry with a binding constant of similar to 1.0 x 10(5) M-1. NMM does not interact with an antiparallel conformation of Tel22 in sodium buffer and is the second example in the …