Novel Dna Origami Based Lateral Flow Assay Development, Adrienne Walker
Dec 2018
Novel Dna Origami Based Lateral Flow Assay Development, Adrienne Walker
Adrienne Walker
Lateral flow assays (LFA) are used for point-of-care qualitative diagnostics of an analyte of interest, often in non-laboratory environments. Traditionally, the format of a lateral flow assay utilizes immobilized antibodies on a membrane as the capture probe in conjunction with a reporting immunological recognition system for an analyte captured between them in a sandwich format. However, there are several shortcomings of antibodies which recommend their replacement with other recognition elements if possible. Among the reasons for seeking alternatives are the long time required to raise and identify a selective and strongly binding antibody, the cost of antibodies, their poor shelf …
Alkali Cation Effects On Redox-Active Formazanate Ligands In Iron Chemistry, Daniel L J Broere, Brandon Q. Mercado, Eckhard Bill, Kyle M. Lancaster, Stephen Sproules, Patrick L. Holland
Dec 2017
Alkali Cation Effects On Redox-Active Formazanate Ligands In Iron Chemistry, Daniel L J Broere, Brandon Q. Mercado, Eckhard Bill, Kyle M. Lancaster, Stephen Sproules, Patrick L. Holland
Daniel Broere
Non-covalent interactions of organic moieties with Lewis acidic alkali cations can greatly affect
structure and reactivity. Herein, we describe the effects of interactions with alkali metal cations
within a series of reduced iron complexes bearing a redox-active formazanate ligand, in terms
of structures, magnetism, spectroscopy, and reaction rates. In the absence of a crown ether to
sequester the alkali cation, dimeric complexes are isolated wherein the formazanate has
rearranged to form a five-membered metallacycle. The dissociation of these dimers is
dependent on the binding mode and size of the alkali cation. In the dimers, the formazanate
ligands are radical dianions, …
Supplemental Information: Alkali Cation Effects On Redox-Active Formazanate Ligands In Iron Chemistry, Daniel L J Broere
Dec 2017
Supplemental Information: Alkali Cation Effects On Redox-Active Formazanate Ligands In Iron Chemistry, Daniel L J Broere
Daniel Broere
No abstract provided.
Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material For 29si Magnetic Resonance Imaging, Hyeonglim Seo, Ikjang Choi, Nicholas Whiting, Jingzhe Hu, Quy S. Luu, Shivanand Pudakalakatti, Caitlin Mccowan, Yaewon Kim, Niki Zacharias Millward, Seunghyun Lee, Pratip Bhattacharya, Youngbok Lee
Dec 2017
Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material For 29si Magnetic Resonance Imaging, Hyeonglim Seo, Ikjang Choi, Nicholas Whiting, Jingzhe Hu, Quy S. Luu, Shivanand Pudakalakatti, Caitlin Mccowan, Yaewon Kim, Niki Zacharias Millward, Seunghyun Lee, Pratip Bhattacharya, Youngbok Lee
Nicholas Whiting
Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for 29Si magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their 29Si MR signals; the particles demonstrated long 29Si spin-lattice relaxation (T1) times (~25 mins), which suggests potential applicability for medical imaging. Furthermore, 29Si hyperpolarization levels were sufficient to allow 29Si MRI in phantoms. These results underscore the potential of porous …
