Chemistry Commons^™

Understanding The Antioxidant Mechanism Of Inorganic Selenium, Oxo- Sulfur, And Polyphenol Compounds, And The Biological Implications Of Functionalized Nanoparticles, Ria Ramoutar

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Inorganic selenium, oxo-sulfur, and polyphenol compounds are found in foods and dietary supplements, and are recognized for their nutritional benefits and their potential to treat or prevent diseases caused by oxidative stress. In our experiments to determine the effects of inorganic selenium compounds on iron-mediated DNA damage, Na₂SeO₃3 and SeO₂ exhibit antioxidant and pro-oxidant activities depending on concentrations of both the compound and hydrogen peroxide. Additional experiments demonstrate that iron coordination is a novel mechanism responsible for the observed activities. In similar experiments, oxo-sulfur compounds prevent Cu+/ H₂O₂-mediated DNA damage significantly …