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Porphyrin Derivatives And Photodynamic Therapy Effects On Triple Negative Breast Cancer, Sarah Rogers, Joseph E. Bradshaw, Timothy E. Hayes
Porphyrin Derivatives And Photodynamic Therapy Effects On Triple Negative Breast Cancer, Sarah Rogers, Joseph E. Bradshaw, Timothy E. Hayes
Scholars Day
There are limited effective options for treatment of triple negative breast cancer (TNBC) due to its lack of the three receptors typically used to target breast cancer. The use of photodynamic therapy (PDT) to kill cells that take up light-absorbing compounds (PDT agents) may be an effective option to treat TNBC. We tested the efficacy of modified porphyrins as PDT agents against cells from TNBC. We compared these to Foscan, which is similar in structure to porphyrins and has been approved for use in Europe. Our 1st goal was to measure which porphyrins were taken up best by TNBC cells. …