Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Chemistry
Unexpected Synthesis Of 1,3,5-Triarly-1,5-Diketones From Aryl Ketones Via Di-Enamine Mechanism, Bin Liu, Junfeng Wang, Yi Pang, Zemei Ge, Runtao Li
Unexpected Synthesis Of 1,3,5-Triarly-1,5-Diketones From Aryl Ketones Via Di-Enamine Mechanism, Bin Liu, Junfeng Wang, Yi Pang, Zemei Ge, Runtao Li
Yi Pang
An unexpected reaction of aryl ketone with acetohydrazone of aromatic aldehyde via 1,2-di-enamine/diiminium mechanism was discovered, leading to efficient synthesis of 1,3,5-triaryl-1,5-diketones in good to excellent yields. (C) 2014 Elsevier Ltd. All rights reserved.
Binding-Induced, Turn-On Fluorescence Of The Egfr/Erbb Kinase Inhibitor, Lapatinib, James N. Wilson
Binding-Induced, Turn-On Fluorescence Of The Egfr/Erbb Kinase Inhibitor, Lapatinib, James N. Wilson
James N Wilson
We report the photophysical properties, binding-induced turn-on emission, and fluorescence imaging of the cellular uptake and distribution of lapatinib, an EGFR/ERBB inhibitor. Lapatinib, a type II, i.e. inactive state, inhibitor that targets the ATP binding pocket of the EGFR family of receptor tyrosine kinases. DFT calculations predict that the 6-furanylquinazoline core of lapatinib should exhibit an excited state with charge transfer character and an S0 to S1 transition energy of 3.4 eV. Absorption confirms an optical tran- sition in the near UV to violet, while fluorescence spectroscopy shows that photoemission is highly sensi- tive to solvent polarity. The hydrophobicity of …