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Full-Text Articles in Chemistry
Design And Synthesis Of Protein-Protein Interaction Inhibitor Scaffolds, David B. Badger
Design And Synthesis Of Protein-Protein Interaction Inhibitor Scaffolds, David B. Badger
USF Tampa Graduate Theses and Dissertations
Many currently relevant diseases such as cancer arise from altered biological pathways that rely on protein-protein interactions. The proteins involved in these interactions contain certain functional domains that are responsible for the protein's biological activities. These domains consist of secondary structural elements such as α-helices and Β-sheets which are at the heart of the protein's biological activity. Therefore, designing drugs that inhibit protein-protein interactions by binding to these key secondary structural elements should provide an effective treatment for many diseases. Presented in this dissertation are the designs, syntheses, and biological evaluations for both novel α-helix and novel Β-sheet mimics.
The …
Functionalization Of Resorcinarenes And Study Of Antimicrobial Activity, Kirankirti Muppalla
Functionalization Of Resorcinarenes And Study Of Antimicrobial Activity, Kirankirti Muppalla
USF Tampa Graduate Theses and Dissertations
Cavitands are very important class of compounds in supramolecular chemistry. These molecules contain rigid enforced cavity,and have attracted considerable attention in supramolecular chemistry as building blocks for the construction of carcerands, hemicarcerands, and other host guests complexes. Nearly 40 years ago, Niederl and Vogel laid foundation for the study of such type of condensation reactions. In our laboratory we are involved in synthesis of resorcinarenes with readily available substrates such as resorcinol and aldehydes to form a cyclic tetramer.
Herein, I present detailed studies about the functionalization of the synthesized tetramers and their antimicrobial activity. Octahydroxy resorcinarenes were synthesized and …